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2025 ICD-10-CM code R87.81

High risk human papillomavirus (HPV) DNA test positive from female genital organs.

Code R87.81 should not be used to report anogenital warts (A63.0).It is important to use the appropriate code for the specific high-risk HPV type detected if available. The seventh character extension should be used to specify the site of specimen collection if applicable.

Medical necessity for HPV DNA testing is determined by clinical guidelines and may vary depending on the patient's age, risk factors, and clinical presentation.Generally, HPV DNA testing is indicated for primary cervical cancer screening in women over a certain age, follow-up of abnormal Pap smears, and as part of the evaluation of certain gynecologic symptoms.

The clinician is responsible for ordering the HPV DNA test, interpreting the results, and providing appropriate counseling and follow-up care based on the test results and the patient's individual circumstances.This may include referral to a specialist (e.g. gynecologist, oncologist) for further evaluation and management.

In simple words: A test has detected the presence of high-risk types of human papillomavirus (HPV) in the female genital area. These HPV types are linked to a higher chance of developing certain cancers.

High risk human papillomavirus (HPV) DNA test positive from female genital organs. This indicates the presence of high-risk HPV types in the female genital tract, which are associated with an increased risk of cervical and other anogenital cancers.It is important to distinguish this code from codes for anogenital warts or condyloma acuminatum (A63.0), which are clinical manifestations of HPV infection, not the direct laboratory finding of high-risk HPV DNA.

Example 1: A 30-year-old female undergoes routine cervical cancer screening and the HPV DNA test result is positive for high-risk HPV.Further evaluation with colposcopy and biopsy may be indicated., A 45-year-old female presents with abnormal vaginal bleeding.An HPV DNA test is performed, which is positive for high-risk HPV. Additional workup is performed to evaluate for cervical or other gynecologic malignancies., A 25-year-old female with a history of abnormal Pap smears undergoes an HPV DNA test, which is positive for high-risk HPV.The patient is monitored closely with regular Pap smears and/or colposcopy.

Documentation should include the type of HPV DNA test performed, the specific high-risk HPV types detected, the site of specimen collection (cervix, vagina, vulva), and any associated signs, symptoms, or relevant medical history. The rationale for ordering the test should also be documented.

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