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BETA v.3.0

2025 ICD-10-CM code T38.5X5A

Adverse effect of other estrogens and progestogens, initial encounter.

Use a secondary code from Chapter 20 (External causes of morbidity) to identify the cause of the adverse effect, if applicable. If a retained foreign body is present, use an additional code from Z18. Use an additional code to specify manifestations of poisoning or underdosing.

Use A for initial encounter

The adverse effect must be clinically significant and require medical attention.

IMPORTANT:T38.5X5D for subsequent encounter

In simple words: This code indicates a negative reaction to estrogen or progestogen medications (not birth control pills) during the first visit for this issue.

This code represents an adverse effect resulting from the use of estrogens and progestogens, excluding oral contraceptives, during the initial encounter.

Example 1: A patient presents for the first time with vaginal bleeding after starting hormone replacement therapy containing estrogens and progestogens., A patient experiences nausea and vomiting during the initial phase of treatment with estrogen and progestogen for menopausal symptoms., A patient develops skin rash after the first dose of injectable estrogens and progestogens for fertility treatment.

Details of the adverse reaction, the specific estrogen and progestogen medication, and the timing of the reaction in relation to the medication administration.

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