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2025 CPT code 36514

Therapeutic apheresis; plasmapheresis.

Follow the official CPT coding guidelines for this procedure, particularly those related to the inclusion of all lesser order catheterizations in the approach, additional catheterizations within the same family of arteries, and separate coding for additional first-order catheterizations in different vascular families.

Modifiers may apply depending on the circumstances of the procedure.Consult the CPT manual and payer specific guidelines for a comprehensive understanding of applicable modifiers.

Medical necessity for therapeutic apheresis is established when the patient presents with a condition that is responsive to this treatment modality and where the benefits outweigh the risks. The condition must be documented and linked to the clinical indications supporting the necessity of the procedure.

The physician responsible for the patient's overall care orders the procedure. Apheresis specialists or trained nurses typically perform the procedure, under the physician's supervision. Post-procedure care is also the responsibility of the ordering physician.

IMPORTANT:For collection of a specimen from an established catheter, use 36592. For collection of a specimen from a completely implantable venous access device, use 36591.For therapeutic apheresis with removal of white blood cells, see 36511; for red blood cells, see 36512; for platelets, see 36513; and for therapeutic apheresis with extracorporeal selective adsorption, selective filtration, and plasma reinfusion, see 36516.

In simple words: This procedure uses a machine to clean your blood.It takes out the liquid part of your blood (plasma) that contains harmful things, then puts the rest of your blood back in. This helps treat several medical problems.

Therapeutic apheresis, specifically plasmapheresis, involves the removal of plasma from whole blood using specialized equipment. The remaining blood components (red blood cells, white blood cells, and platelets) are returned to the patient, often with the addition of a volume replacement fluid like saline or albumin. This procedure is used to treat various conditions where harmful substances or cells are present in the plasma.

Example 1: A patient with Guillain-Barré syndrome undergoes plasmapheresis to remove antibodies attacking the peripheral nerves., A patient with thrombotic thrombocytopenic purpura (TTP) receives plasma exchange to remove von Willebrand factor multimers., A patient with severe hyperlipidemia undergoes lipoprotein apheresis to reduce abnormally high cholesterol levels.

*Detailed patient history including symptoms and diagnosis.*Complete blood count (CBC) and other relevant laboratory results.*Physician's order specifying the type of apheresis and volume to be removed.*Documentation of the procedure itself, including the volume of plasma removed, the type of replacement fluid used, and any complications.*Post-procedure monitoring data.*Informed consent from the patient.

** Always refer to the most current CPT and payer guidelines for accurate coding and reimbursement.This information is subject to change.

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