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2025 CPT code 45349

Flexible sigmoidoscopy with endoscopic mucosal resection.

Refer to the official CPT manual for the most up-to-date coding guidelines and instructions.

Modifiers may apply depending on the circumstances of the procedure (e.g., modifier 52 for reduced services, 53 for discontinued procedure).

Medical necessity for this procedure would be established through the presence of a clinically significant lesion in the rectum or sigmoid colon requiring resection for diagnostic or therapeutic purposes. This could include symptoms such as rectal bleeding, changes in bowel habits, abdominal pain, or the presence of a suspicious polyp.

The physician or qualified endoscopist is responsible for the entire procedure, from patient preparation and anesthesia administration to insertion of the sigmoidoscope, lesion identification and resection, hemostasis, and post-procedure care.

IMPORTANT:Do not report 45349 with 45331, 45335, 45338, 45350, or 45330 for the same lesion.

In simple words: The doctor uses a thin, flexible tube with a camera (sigmoidoscope) to look inside the rectum and sigmoid colon (part of the large intestine). If they find an abnormal area (lesion), they remove a small piece of tissue (mucosal resection) to check it or treat the problem.

This CPT code encompasses a flexible sigmoidoscopy procedure involving the resection of mucosal tissue.The procedure uses a flexible sigmoidoscope to visualize the rectum and sigmoid colon. After identifying a lesion, a submucosal injection may be administered to elevate the lesion for easier resection using a snare or other suitable method.Hemostasis is ensured after the excision.This code is for diagnostic or therapeutic purposes. Note that this code should not be reported with codes 45331, 45335, 45338, 45350, or 45330 for the same lesion.

Example 1: A patient presents with rectal bleeding and a suspicious polyp identified during a prior exam. The physician performs a flexible sigmoidoscopy with endoscopic mucosal resection of the polyp to obtain a tissue sample for biopsy and to potentially remove the polyp if benign., A patient experiences chronic constipation and abdominal discomfort.A flexible sigmoidoscopy with EMR is performed to rule out any underlying lesions, such as polyps, that could be contributing to these symptoms., During a routine colonoscopy, a small lesion is found in the sigmoid colon. The physician decides to proceed with a flexible sigmoidoscopy with EMR to remove the lesion for diagnostic and therapeutic purposes, potentially avoiding a more extensive surgical intervention.

** Always refer to the most current CPT codebook and payer guidelines for accurate coding and reimbursement practices.Specific details regarding the global period and relative value units should be verified with the relevant payer.

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