Start New EnglishEspañol中文РусскийالعربيةTiếng ViệtFrançaisDeutsch한국어Tagalog Library Performance
BETA v.3.0

2025 CPT code 64612

Chemodenervation of muscles innervated by the facial nerve on one side of the face.

Report code 64612 per area (left or right), not per injection. If multiple injections are given on the same side, only one code is reported.Modifiers LT (left) or RT (right) should be appended.Modifier 50 is used for bilateral procedures. Payer specific guidelines may vary.

Modifiers LT (left) and RT (right) are used to specify the side of the injection. Modifier 50 (bilateral procedure) may also be used if both sides are treated.

The procedure is medically necessary when conservative treatments have failed to alleviate symptoms of blepharospasm, hemifacial spasm, or other conditions causing involuntary muscle contractions.Documentation should clearly show the severity of the condition and the justification for using chemodenervation.

The physician injects botulinum toxin into specific muscle sites on one side of the face to achieve denervation, thereby alleviating symptoms.

IMPORTANT:For bilateral procedures, report 64612 with modifier 50.Code 64615 is used for bilateral chemodenervation of muscles innervated by the facial, trigeminal, cervical spinal, and accessory nerves (e.g., for chronic migraine).

In simple words: This procedure uses an injection to weaken facial muscles on one side of the face, relieving conditions like uncontrolled eyelid closing or painful muscle spasms.

This procedure involves the unilateral chemodenervation of muscles innervated by the facial nerve.A chemical agent, such as botulinum toxin, is injected into specific muscles to temporarily weaken or paralyze them. This is commonly used to treat conditions like blepharospasm (uncontrolled eyelid closure) and hemifacial spasm (involuntary muscle contractions on one side of the face).

Example 1: A patient presents with blepharospasm (involuntary eyelid closure). The physician injects botulinum toxin into the orbicularis oculi muscles of the left eye to reduce muscle spasms and improve eyelid opening., A patient experiences hemifacial spasm (involuntary facial muscle contractions) on the right side of their face. The physician performs a chemodenervation procedure, injecting botulinum toxin into the affected muscles to reduce spasms and pain., A patient has severe facial wrinkles.The physician uses botulinum toxin injections to reduce wrinkle appearance. Note that this use is considered cosmetic and may not be covered by insurance.

A covered diagnosis (e.g., blepharospasm, hemifacial spasm).Precise location(s) of injection.Dosage of botulinum toxin administered.Pre- and post-injection assessment of symptoms.Patient's response to the treatment.

** The supply of the chemodenervation agent (e.g., botulinum toxin) is reported separately using appropriate J-codes.Ultrasound guidance may be reported separately using appropriate codes. Always check payer-specific guidelines for coverage and reimbursement.

** Only Enterprise users with EHR integration can access case-specific answers. Click here to request access.

Discover what matters.

iFrame™ AI's knowledge is aligned with and limited to the materials uploaded by users and should not be interpreted as medical, legal, or any other form of advice by iFrame™.