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BETA v.3.0

2025 CPT code 64647

Chemodenervation of trunk muscle(s); 6 or more muscles.

Report only one unit of either 64646 or 64647 per session. Do not report a destruction code when the therapy used is not destructive (e.g., pulsed radiofrequency); use 64999 instead.For chemodenervation codes, the supply of the agent is reported separately.

Modifiers may be applicable. Refer to current CPT guidelines and payer policies for specific modifier usage related to this code.

Medical necessity should be established by supporting documentation demonstrating the patient's condition (e.g., spasms, pain) and the clinical rationale for the chemodenervation procedure.Prior treatments and their effectiveness should also be noted.

In simple words: A doctor injects a medication, like Botox, into six or more muscles in the torso (chest, abdomen, and back) to treat muscle pain and spasms.

This code represents the injection of a chemodenervation agent, such as botulinum toxin, into six or more trunk muscles.The purpose is to interrupt nerve signals, causing paralysis of the targeted muscles to relieve pain and spasms. The trunk includes the thorax, abdomen, and back, but excludes the neck, head, and extremities.

Example 1: A patient with severe back spasms affecting six or more muscles receives botulinum toxin injections into the affected muscles to alleviate pain and spasms., A patient with abdominal muscle spasms resulting from a neurological condition receives chemodenervation injections in six abdominal muscles., A patient with chest wall pain and muscle spasms due to an injury undergoes chemodenervation of six or more muscles in the affected area.

Documentation should include details about the specific trunk muscles injected, the chemodenervation agent used, the dosage administered, the indication for the procedure (e.g., diagnosis of spasms or pain), and the patient's response to treatment.

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