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2025 CPT code 80305

Presumptive drug test(s) using direct optical observation methods (e.g., dipsticks, cups, cards) for any number of drug classes; includes sample validation.

* Only one code from 80305-80307 can be reported per date of service.* Sample validation tests (e.g., creatinine, pH) are not separately billable.* For multiple specimen types, use modifier 59.

Modifier 59 (distinct procedural service) may be applied if the same procedure is performed on more than one specimen type (e.g., blood and urine).

Medical necessity for 80305 is established by the ordering physician's clinical judgment based on the patient's medical history, symptoms, and the need for rapid screening of potential drug use or abuse.This is typically relevant in urgent care, emergency room settings, or for routine monitoring in compliance programs.

The clinical laboratory analyst performs all technical aspects of the test(s) on a patient specimen, including sample validation to ensure specimen integrity. This involves using methods for direct optical observation to screen for the presence or absence of drug classes, providing qualitative (positive/negative) results.

IMPORTANT:Related codes include 80306 (instrument-assisted direct optical observation) and 80307 (instrumented chemistry analyzers).

In simple words: This lab test checks for various drugs in a sample (like urine) using a method where the results are visually read (e.g., using a dipstick). It's a quick screening test, and the lab also checks to make sure the sample is valid.Only one charge is made per day, regardless of how many drugs are checked for.

This CPT code reports presumptive drug testing where results are read by direct optical observation only, without instrument assistance.The procedure screens for any number of drug classes and includes all sample validation procedures (e.g., pH, specific gravity, nitrite).Examples of methods include dipsticks, cups, cards, and cartridges. Only one code 80305 is reported per date of service, irrespective of the number of drug classes tested.

Example 1: A patient presents to the emergency room following a suspected drug overdose. A rapid presumptive drug screen (80305) is performed using a urine dipstick to quickly identify potential drugs for immediate treatment., As part of a routine pre-employment physical, a urine sample is collected and analyzed for a presumptive drug screen (80305) using a rapid immunoassay card, providing a quick overview of potential drug usage., A probation officer orders a urine drug screen (80305) as part of routine drug monitoring for a patient on parole. The test helps to verify compliance with their court-mandated drug-free conditions.

* Patient demographics* Date and time of specimen collection* Type of specimen (e.g., urine)* Method used for drug screening* Results of the drug screen* Documentation of any sample validation procedures performed

** This code encompasses a wide range of presumptive drug testing methodologies.Always refer to the most recent CPT manual and payer guidelines for definitive billing practices.

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