2025 CPT code 80330
Effective Date: N/A Drug Assay Procedures Feed
Analgesics, non-opioid; 3-5
Modifier 59 may be used to indicate that the same procedure was performed on more than one specimen type (e.g., blood and urine) on the same day.
Medical necessity must be established for each drug test performed. The documentation must clearly support the reason for the test and its relevance to the patient's condition and treatment plan.
The lab analyst performs the test to measure or detect the presence of three to five non-opioid analgesics in a patient specimen.
In simple words: This test measures the levels of 3 to 5 different pain medications (not including opioids) in a patient's sample (like blood or urine). It helps doctors check for overdoses or see if patients are taking their medications as prescribed.
The lab analyst measures the amount of or detects the presence of three to five nonopioid analgesics, such as acetaminophen or salicylate, in a patient specimen. A typical specimen may be urine or serum. The lab analyst may use a methodology such as high–performance liquid chromatography. This method forces a combination of a pressurized liquid and the specimen through a specially designed column. This method separates the analyte, which is the substance the analyst is measuring, from the mixture, allowing a sensitive detector to quantitate the analyte. Quantitation refers to measuring the exact amount of a substance. For this code, testing may be quantitative; qualitative, showing the specimen is positive or negative for the analyte; or a combination. Although not limited to testing for a specific condition, clinicians may order this test to help diagnose whether a patient has taken an overdose of the pain medication or to determine whether a patient is complying with a prescribed regimen.
Example 1: A patient presents to the emergency department with suspected acetaminophen overdose. A definitive drug test for non-opioid analgesics (including acetaminophen, ibuprofen, and salicylate) is ordered to confirm the diagnosis and guide treatment., A patient with chronic pain is prescribed a regimen of multiple non-opioid analgesics. Regular drug testing is performed to monitor therapeutic levels and ensure compliance with the prescribed medications., A physician suspects a patient is not taking their prescribed pain medications as directed. A drug test is ordered to detect the presence or absence of the prescribed non-opioid analgesics.
Documentation should include the reason for testing (e.g., overdose, therapeutic monitoring, compliance), the specific non-opioid analgesics being tested, the specimen type, and the date and time of collection.