2025 CPT code 80337

Definitive identification of six or more tricyclic and other cyclical antidepressants in a patient specimen.

Refer to the current CPT manual for the most up-to-date guidelines on coding for drug testing.Specific guidelines around quantitative vs. qualitative results and specimen type must be followed.

Modifiers may be applicable depending on the circumstances.Modifier 59 (Distinct procedural service) might be used if the same procedure is done on multiple specimen types.Other modifiers may be necessary for specific payer requirements or based on NCCI edits.

Medical necessity is established based on the clinical indication for the test, such as suspected overdose, therapeutic drug monitoring to assess compliance or efficacy, or as part of a broader toxicology screen to evaluate for potential impairment or contribution to a clinical event.

The clinical responsibility lies with the laboratory analyst who performs the test, analyzes the results, and reports them to the ordering physician. The ordering physician is responsible for the medical decision-making based on these results.

IMPORTANT 80335 (one or two tricyclic antidepressants), 80336 (three to five tricyclic antidepressants). If the specific analyte isn't listed in 80320-80373, use unlisted definitive procedure codes 80375, 80376, or 80377.

In simple words: This lab test checks for six or more types of antidepressants in a sample from the patient.The test shows if the antidepressants are present and might measure the amount present. This helps doctors know if someone has taken too many or if they're taking their medicine correctly.

This CPT code reports the definitive identification of six or more tricyclic and other cyclical antidepressants.The testing may be qualitative (positive/negative), quantitative (measuring the exact amount), or a combination.The specimen type can vary (e.g., serum, plasma, urine), and methods like high-performance liquid chromatography (HPLC) are commonly used.This test helps determine drug overdose or compliance with a prescribed regimen.

Example 1: A patient presents to the emergency department following a suspected overdose of antidepressants.A blood sample is sent to the lab for analysis using code 80337 to identify and quantify the antidepressants consumed., A psychiatrist orders 80337 to monitor a patient's adherence to their prescribed antidepressant regimen.A urine sample is used to check for the presence and levels of six or more specific antidepressants., A toxicology screen is ordered for a patient involved in a motor vehicle accident to rule out antidepressant influence.Blood and urine are both tested, and 80337 is used to identify and quantify the various antidepressants present, using modifier 59 for different specimen types.

** This code encompasses a broad range of tricyclic and other cyclical antidepressants; consult the definitive drug classes listing within the CPT manual for a comprehensive list of included analytes. The selection of this code depends on the number of analytes identified, not the capacity of the analytical method.Always adhere to all relevant coding guidelines and payer-specific rules for accurate billing.

  • Revenue Code: T1H (LAB TESTS - OTHER (NON-MEDICARE FEE SCHEDULE))
  • RVU: Information not available in provided text.RVUs vary based on geographic location and payer.
  • Global Days : Not applicable.
  • Payment Status: Active
  • Modifier TC rule: Not applicable for this code.
  • Fee Schedule : Data unavailable. Fee schedules vary by payer and location. Check your local payer's fee schedule for historical data.
  • Specialties:Clinical Chemistry, Toxicology, Psychiatry, Emergency Medicine
  • Place of Service:Office, Hospital (Inpatient and Outpatient), Urgent Care Facility, Laboratory
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