2025 CPT code 81313
Effective Date: N/A Pathology and Laboratory Procedures > Molecular Pathology Procedures Feed
PCA3/KLK3(prostate cancer antigen 3 [non-protein coding]/kallikrein-related peptidase 3 [prostate specific antigen]) ratio (eg, prostate cancer)
Modifiers may be applicable depending on the circumstances, including modifier 26 if only the interpretation and report are performed, or modifier 59 for a distinct procedural service.
This test is medically necessary when there is clinical suspicion of prostate cancer, or when monitoring for recurrence in patients with a history of the disease. It aids in risk assessment and treatment planning.
The lab analyst performs all technical steps involved in the test, from nucleic acid extraction to amplification and detection, and measures the PCA3 to KLK3 ratio.
In simple words: This test evaluates the ratio between two genes: nonprotein coding prostate cancer antigen 3 (PCA3) and prostate specific antigen kallikrein related peptidase 3 (KLK3). It is commonly used to help diagnose and monitor prostate cancer.
Evaluation of the ratio between PCA3 and KLK3 can confirm the diagnosis in nearly all patients with prostate cancer, but other tests may also be necessary to evaluate the genetic status and confirm the diagnosis.
Example 1: A 60-year-old male patient presents with elevated PSA levels. A PCA3/KLK3 ratio test is ordered to assess the risk of prostate cancer., A patient with a previous history of prostate cancer undergoes a PCA3/KLK3 ratio test to monitor for recurrence., A physician orders a PCA3/KLK3 ratio test to confirm a suspected diagnosis of prostate cancer in a patient with urinary symptoms.
Documentation should include the reason for testing, relevant clinical findings, and any previous prostate cancer history.
** Preparation work preceding cell lysis, such as tissue selection or microdissection, can be reported separately. A single unit of 81313 represents one evaluation of the PCA3/KLK3 ratio. Additional information about the product can be found on iFrameAI
- Revenue Code: Z2
- Specialties:Urology, Oncology, Pathology
- Place of Service:Independent Laboratory, Office