2025 CPT code 81599
(Active) Effective Date: N/A Pathology and Laboratory Procedures > Multianalyte Assays with Algorithmic Analyses Feed
Unlisted multianalyte assay with algorithmic analysis. (Do not use 81599 for multianalyte assays with algorithmic analyses listed in Appendix O)
Modifiers may be applicable to further specify the circumstances of the service. Refer to current CPT modifier guidelines for appropriate use.
Medical necessity must be established by documenting the clinical rationale for performing the test.The ordering physician should clearly document the patient's signs, symptoms, or other clinical findings that justify the need for the test, as well as how the test results will impact the patient's management.
The laboratory analyst is responsible for performing the MAAA procedure according to the laboratory's established protocol. This includes preparing the sample, running the assays, interpreting the results in conjunction with the algorithm, and reporting the final result.
In simple words: This code represents a lab test that analyzes multiple components of a sample (like blood or tissue) using a special formula to calculate a result, usually a risk score or probability, which is more meaningful than individual test results.It's used when a more specific code for the test doesn't exist.
This code is used to report a multianalyte assay with algorithmic analysis (MAAA) when a specific Category I code or an administrative code in Appendix O does not exist for the performed procedure.MAAAs involve analyzing multiple results from various analyses (e.g., molecular pathology, fluorescent in situ hybridization, non-nucleic acid based assays) and applying an algorithm to generate a score or probability.These tests are typically unique to a single clinical laboratory or manufacturer.
Example 1: A patient with suspected autoimmune disease undergoes a novel MAAA that analyzes multiple antibodies and proteins in their blood to calculate a probability of having the disease., A cancer patient's tumor tissue is analyzed using a MAAA that measures the expression of several genes to assess their risk of recurrence., A transplant recipient undergoes a MAAA that measures several biomarkers to predict the likelihood of organ rejection.
Documentation should include a detailed description of the procedure performed, the methodology used, the results of the individual assays, the algorithm used to calculate the final result, and the clinical indication for the test.A copy of the laboratory report should also be included.
- Revenue Code: Z2 (UNDEFINED CODES)
- Specialties:Pathology, Oncology, Immunology, Transplantation
- Place of Service:Independent Laboratory, Hospital Laboratory