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2025 CPT code 82670

This code reports the quantitative measurement of total estradiol in a patient specimen (e.g., blood) using methods like LC-MS/MS.

Adhere to all applicable CPT coding guidelines for chemistry procedures, including those related to specimen handling, test performance, and reporting of results.Refer to current CPT codebook for the most up-to-date information.

Modifiers may apply depending on the circumstances of service.Refer to the CPT codebook for details on appropriate modifier usage.

Medical necessity for estradiol testing is established when there is a clinical indication to assess hormonal status related to infertility evaluation, monitoring of hormone replacement therapy, investigation of menstrual irregularities, evaluation of precocious or delayed puberty, or investigation of suspected hormonal imbalances in both men and women.

The clinical laboratory analyst performs the technical aspects of the test, quantifying total estradiol levels. The ordering physician interprets the results in the context of the patient's clinical presentation. Specimen collection may be a separate procedure performed by a different provider.

IMPORTANT:Code 82681 (free estradiol) should be used for free estradiol measurement.For estradiol response panels, use code 80415. Other estrogen fractions include estriol (82677), estrone (82679), and fractionated estrogens (82671). Code 82672 quantifies total estrogens.

In simple words: This lab test measures the amount of estradiol (a type of estrogen) in your blood.It helps doctors understand your hormone levels and diagnose problems with fertility, reproduction, or other hormone-related issues.

CPT code 82670 represents the analytical procedure for the quantitative determination of total estradiol levels in a patient sample, such as serum or blood.The measurement is typically performed using a method like liquid chromatography-tandem mass spectrometry (LC-MS/MS). This test assesses the total estradiol concentration, not the free estradiol fraction.Results are used to evaluate hormonal status in both men and women, aiding in the diagnosis and management of conditions related to fertility, reproductive health, and other hormonal imbalances.

Example 1: A 35-year-old woman undergoing in vitro fertilization (IVF) treatment has her total estradiol levels monitored throughout the stimulation cycle to assess ovarian response and guide medication adjustments., A 48-year-old woman experiencing menopausal symptoms has her estradiol level tested to evaluate the severity of estrogen deficiency and guide hormone replacement therapy decisions., A 28-year-old male patient presenting with symptoms of gynecomastia (breast enlargement) undergoes estradiol testing to assess possible hormonal imbalances, potentially linked to hyperestrogenism.

The requisition should clearly specify the test as "total estradiol" and the specimen type (e.g., serum, plasma). The patient's demographic information, clinical history, and the reason for ordering the test must be documented.

** This code is for the total estradiol assay.Do not confuse with other estrogen tests, such as free estradiol or other specific estrogen fractions.

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