2025 CPT code 82671

Fractionation and quantitation of estrogens in serum or urine.

Follow CPT guidelines for laboratory and pathology coding.Adhere to all payer-specific guidelines.

Modifiers may be applicable depending on the circumstances of service. Consult the most up-to-date CPT modifier guidelines.Modifier 90 (Reference Laboratory) may be used.Other modifiers could include those related to place of service and other circumstances.

Medical necessity is established when the ordering physician uses the results of this test to make a diagnosis, guide treatment decisions (e.g. hormone replacement therapy, IVF management), or monitor the response to treatment.The test should be clinically indicated based on the patient's symptoms, medical history, and physical examination.

The clinical responsibility lies with the laboratory analyst who performs the quantitative analysis of estrogen fractions. The ordering physician is responsible for interpreting the results within the context of the patient's clinical presentation and history.

IMPORTANT For individual estrogen fraction orders, use 82670 (estradiol), 82677 (estriol), and 82679 (estrone). For total estrogen quantitation, use 82672.

In simple words: This lab test measures the different types of estrogen in your blood or urine.Estrogen is a hormone important for women's health. The test helps doctors understand hormone levels and make diagnoses related to hormone issues.

This CPT code encompasses the laboratory analysis of estrogen fractions (primarily estradiol and estrone, with estriol being a minor component except during pregnancy) in either serum or urine samples.The procedure involves quantitative measurement of each estrogen fraction.Methodology typically utilizes liquid mass spectrometry, which bombards molecules with electrons and identifies hormones by mass or fragmentation patterns.

Example 1: A 35-year-old female patient presents with irregular menstrual cycles and suspected polycystic ovary syndrome (PCOS). The physician orders this test to assess her estrogen levels and help diagnose PCOS., A 48-year-old woman is experiencing menopausal symptoms, including hot flashes and vaginal dryness.Estrogen fractionation is ordered to determine the specific type and level of estrogen deficiency to guide hormone replacement therapy., A 28-year-old woman undergoing in-vitro fertilization (IVF) treatment needs regular monitoring of her estrogen levels to assess follicle development and optimize the timing of egg retrieval.

* Patient demographics and relevant clinical history.* Reason for ordering the test.* Specimen collection date and time.* Method used for specimen collection (serum or urine).* Laboratory report with quantitative values for estradiol, estrone, and estriol.

** This code is for the fractionation and quantitation of estrogens; it does not include other related tests such as hormone receptor assays or other hormone assessments.

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