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2025 CPT code 82677

This code reports the quantitative measurement of estriol levels in serum, urine, or placental fluid.

Refer to the current CPT coding guidelines for laboratory services.Always ensure accurate documentation and appropriate code selection based on the specific method used to measure estriol and the sample type collected.

Modifiers may apply depending on the place of service, the type of laboratory, and other factors.Check payer guidelines for applicable modifiers.

Medical necessity is established by the physician's clinical judgment based on the patient's risk factors, such as advanced maternal age, diabetes, family history of birth defects, or other concerns that could affect fetal health.The use of estriol testing as part of a multiple-marker prenatal screening test is generally considered medically necessary.

A laboratory analyst performs this test using methods like radioimmunoassay. Clinicians use the test to assess fetal well-being and maternal health during pregnancy. Low levels might suggest problems like fetal abnormalities or preeclampsia.

IMPORTANT:Related codes include 82670 (estradiol), 82679 (estrone), 82671 (multiple estrogen fractions), 82672 (total estrogens), 82105 (AFP), 84702 (hCG), and 86336 (inhibin A).These are often ordered in conjunction with 82677 as part of multiple-marker prenatal screening tests.

In simple words: This lab test measures the amount of estriol, a type of estrogen hormone, in a sample of your blood, urine, or fluid from the placenta (the organ that nourishes a baby during pregnancy). Low levels may suggest potential problems with the pregnancy or baby’s health. This test is often part of a broader screening process during pregnancy.

CPT code 82677 represents the laboratory procedure for the quantitative determination of estriol levels.The analyte may be measured in serum, urine, or placental fluid.The procedure uses methods such as radioimmunoassay, which employs a radioactive isotope for precise measurement.Low estriol levels during pregnancy may indicate potential issues with the fetus or the mother's health, such as diabetes or preeclampsia.The test is frequently ordered as part of prenatal screening (triple or quad screen) to assess fetal health and detect potential birth defects.

Example 1: A pregnant woman at 16 weeks gestation undergoes a quad screen which includes estriol testing to screen for Down syndrome and other chromosomal abnormalities., A pregnant patient with a history of diabetes is monitored for low estriol levels, which may indicate placental insufficiency., A physician orders serial estriol measurements in a high-risk pregnancy to track fetal health and intervene if levels are significantly low.

Patient demographics, date of service, gestational age of the pregnancy (if applicable), collection method (serum, urine, or placental fluid), and the results of the estriol assay should be documented.The ordering physician's clinical indication for the test should also be documented.

** The estriol test is often performed as part of a panel of tests (e.g., triple or quad screen) to assess fetal health.Abnormal estriol levels should be interpreted in the context of other clinical findings and not in isolation.Always refer to the latest CPT codebook and payer guidelines for the most current coding information.

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