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2025 CPT code 84075

Alkaline phosphatase, serum.

If an analyte (e.g., urinary creatinine) is performed to adjust for urine concentration variations (e.g., microalbumin), report both the ordered analyte and the additional analyte.Do not report calculated values derived from other tests unless specifically ordered by the physician.

Modifier 91 is used for repeat laboratory tests performed on the same day. Modifier 59 may be used to indicate a distinct procedural service. Modifier 90 is used for tests performed by a reference (outside) laboratory.

Medical necessity for this test must be established based on the patient's signs, symptoms, and clinical history.The test is used to investigate or monitor liver or bone conditions and requires appropriate justification.

Laboratory personnel are responsible for performing the test and providing accurate results to the ordering clinician.

IMPORTANT:84078 (alkaline phosphatase, heat stable), 84080 (alkaline phosphatase isoenzymes), and 80076 (hepatic function panel, which includes alkaline phosphatase) are related codes and should not be reported in addition to 84075 if part of the same panel or if the additional testing is not medically necessary.

In simple words: This test measures the level of alkaline phosphatase in your blood.This enzyme is found in several parts of your body, and the test helps doctors check the health of your liver and bones.

This code represents a quantitative measurement of alkaline phosphatase enzyme activity in serum.Alkaline phosphatase is present in several tissues, including liver, bone, intestines, and placenta.

Example 1: A patient presents with abdominal pain, jaundice, and elevated bilirubin. An alkaline phosphatase test is ordered to evaluate potential liver dysfunction or biliary obstruction., A patient with a history of bone pain and fractures undergoes an alkaline phosphatase test to screen for metabolic bone diseases such as Paget's disease., A growing child with skeletal abnormalities has an alkaline phosphatase level checked to assess bone growth and development.

Documentation should include the reason for the test, the specimen source (serum), and the date and time of collection.

** Alkaline phosphatase levels can be elevated in various conditions unrelated to liver or bone disease, such as pregnancy, certain medications, and some infections. Interpretation requires correlation with the patient's clinical presentation and other laboratory results.Consult iFrameAI for the most updated information.

** Only Enterprise users with EHR integration can access case-specific answers. Click here to request access.

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