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2025 CPT code 84112

Qualitative evaluation of cervicovaginal fluid for specific amniotic fluid protein(s) (e.g., placental alpha microglobulin-1 [PAMG-1], placental protein 12 [PP12], alpha-fetoprotein), each specimen.

The code is reported per specimen tested. If multiple specimens are tested from different sources or at different times, the code should be reported for each.

Medical necessity is established by the presence of signs or symptoms suggestive of premature rupture of membranes, such as vaginal discharge, leaking fluid, or a history of PROM. It may also be used in high-risk pregnancies as a preventative measure.

A healthcare provider or laboratory personnel performs this test.The provider collects a cervicovaginal fluid specimen using a swab, mixes it with a solution, and then applies it to a test strip. Results are read after a specified time.

In simple words: This test checks vaginal fluid for proteins that would normally be found in the amniotic sac surrounding a baby. It's used to determine if the sac has ruptured prematurely, which is also known as the water breaking early.

This code represents a qualitative test performed on cervicovaginal fluid to detect the presence or absence of specific amniotic fluid proteins. These proteins, such as placental alpha microglobulin-1 (PAMG-1), placental protein 12 (PP12), and alpha-fetoprotein, can indicate premature rupture of membranes (PROM) in pregnant women.The test is typically performed on each specimen collected.

Example 1: A pregnant woman in her third trimester presents with vaginal discharge and suspects her water might have broken. The physician orders the 84112 test to check for the presence of amniotic fluid proteins., A woman experiences a sudden gush of fluid at 30 weeks of gestation. She goes to the emergency room, and the 84112 test is performed to confirm if it's amniotic fluid., A pregnant patient has a history of premature rupture of membranes. During a routine checkup, her physician orders the 84112 test as a precautionary measure, even though the patient has no current symptoms.

Documentation should include the reason for the test, the date and time of specimen collection, the method used, and the test result. Any relevant clinical findings, such as gestational age, signs of labor, or other symptoms, should also be noted.

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