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2025 CPT code 84378

Quantitative measurement of a single sugar (mono-, di-, or oligosaccharide) in a specimen (urine or stool).

Refer to CPT guidelines for laboratory and pathology procedures.Report each specimen separately.When an analyte is measured in multiple specimens, report separately for each.

Modifiers may apply depending on the circumstances of service, such as modifier 90 (Reference (Outside) Laboratory) if the test is performed by an outside lab.

Medical necessity is established by the physician's clinical judgment based on the patient's symptoms, history, and physical examination findings suggestive of a carbohydrate metabolism disorder requiring evaluation of specific sugar levels.

The clinical laboratory analyzes the provided specimen using appropriate methods to quantify the specific sugar requested. The ordering physician interprets the results within the context of the patient's clinical presentation and other diagnostic information.

IMPORTANT For organ or disease-oriented panels, use codes 80048-80076.If the analyte is not specified by an analyte-specific or method-specific code in the Chemistry (82009-84830) subsection, use unlisted chemistry procedure code 84999.

In simple words: This lab test measures the amount of a specific type of sugar in a sample of your urine or stool. The test is done separately for each sample provided.

This CPT code, 84378, reports the quantitative determination of a single monosaccharide, disaccharide, or oligosaccharide in a patient specimen, such as urine or stool.The analysis is performed on each individual specimen submitted.Multiple specimens from different sources or obtained at different times are reported separately. The method may involve techniques like colorimetry, where the color change after a chemical reaction correlates to the sugar concentration.This test is commonly used in evaluating carbohydrate metabolism disorders like lactose or fructose intolerance.

Example 1: A patient presents with symptoms suggestive of lactose intolerance (diarrhea, bloating after dairy consumption).A stool sample is collected and tested using code 84378 to quantify lactose levels., A patient with suspected fructose malabsorption undergoes testing.A urine sample is analyzed using code 84378 to measure the amount of fructose excreted., A pediatric patient with suspected galactosemia has multiple urine samples collected at different times throughout the day. Each sample is analyzed using 84378 for galactose levels, reported separately.

Patient demographics, date and time of specimen collection, source of the specimen (urine or stool), type of sugar analyzed, and the quantitative result.

** If multiple sugars are measured, use appropriate codes for each.For algorithmically derived scores, use appropriate MAAA codes.

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