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BETA v.3.0

2025 CPT code 84402

Measures the amount of free testosterone in a blood sample.

Follow current CPT coding guidelines for laboratory tests.Report results separately for each specimen collected at different times or from different sources. If calculated from other tests, report only the requested analyte, except when compensating for urine concentration (e.g., urinary creatinine for microalbumin).

Modifiers may be applicable depending on the circumstances of service. Consult the CPT manual for specific modifier usage guidelines and any payer-specific requirements.

Medical necessity for a free testosterone test depends on the clinical presentation and requires appropriate clinical justification.Common reasons include evaluating symptoms of hypogonadism in males (decreased libido, fatigue, erectile dysfunction), investigating suspected endocrine disorders in females (irregular menses, hirsutism), monitoring hormone replacement therapy, and assessing fertility issues.

The clinical responsibility lies with the laboratory personnel who perform the technical aspects of the test, including sample preparation, analysis and reporting of results.The ordering physician is responsible for the medical interpretation of the results and clinical decision-making based on the findings.

IMPORTANT:May be ordered in conjunction with 84403 (Testosterone; total).Consider 81599 (unlisted multianalyte assay with algorithmic analysis) for algorithmically derived scores or probabilities related to testosterone levels.

In simple words: This blood test measures the amount of free testosterone in your body. Free testosterone is the type of testosterone that is active and can be used by your body's cells.It's different from total testosterone, which includes testosterone bound to proteins. This test helps determine if your free testosterone levels are too high or too low.

This test quantitatively measures the level of free testosterone (the unbound, biologically active form of testosterone) in a serum sample.Testosterone is a steroid hormone crucial for sexual development and function in both males and females.The test differentiates free testosterone from testosterone bound to proteins like sex hormone-binding globulin (SHBG) and albumin. Free testosterone is the fraction readily available for cellular uptake and exerts biological effects. The methodology may involve techniques such as chromatography or immunoassay.

Example 1: A 35-year-old male patient presents with symptoms of decreased libido and fatigue.The physician orders a free testosterone test to evaluate for hypogonadism., A 28-year-old female patient is experiencing irregular menstrual cycles and hirsutism.The physician orders a free testosterone test to investigate potential endocrine disorders, such as polycystic ovary syndrome (PCOS)., A 60-year-old male patient is undergoing hormone replacement therapy.The physician orders serial free testosterone measurements to monitor the effectiveness of the treatment and to adjust dosage accordingly.

Patient demographics, date of collection, test requisition indicating medical necessity (reason for the test), and the results of the free testosterone analysis. If multiple specimens were drawn on different dates or from different sources, this should be clearly documented and reported separately for each.

** Accurate interpretation of free testosterone results requires consideration of other hormonal parameters and the clinical context.Reference ranges vary between laboratories and should be used as a guideline, not an absolute threshold.

** Only Enterprise users with EHR integration can access case-specific answers. Click here to request access.

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