2025 CPT code 85410
(Active) Effective Date: N/A Revision Date: N/A Deletion Date: N/A Pathology and Laboratory Procedures - Fibrinolytic factors and inhibitors Hematology and Coagulation Procedures Feed
Alpha-2 antiplasmin assay; a test to measure levels of alpha-2 antiplasmin, a fibrinolytic inhibitor in plasma.
Modifiers 90 and 91 may apply based on the specific circumstances of the testing process (e.g., outside lab, repeat test).
Medical necessity for alpha-2 antiplasmin assay is typically established based on clinical presentation and suspicion of conditions like congenital alpha-2 antiplasmin deficiency, DIC, or hyperfibrinolysis; or for monitoring the effects of fibrinolytic or antifibrinolytic therapies. Specific payer requirements should be verified.
The clinical responsibility lies with the laboratory analyst who performs the technical aspects of the alpha-2 antiplasmin assay, including specimen processing, analysis, and reporting of results.The ordering physician is responsible for medical decision-making based on the results.
- Hematology and Coagulation Procedures
- Hematology and Coagulation Procedures; Fibrinolytic factors and inhibitors
In simple words: This lab test measures the level of alpha-2 antiplasmin in your blood. Alpha-2 antiplasmin helps control blood clotting. The test can help diagnose certain blood clotting disorders and monitor treatment for these conditions.
This CPT code, 85410, represents the analytical procedure for measuring alpha-2 antiplasmin levels in a patient's plasma sample.The test typically employs methods such as chromogenic assays. The process involves mixing the patient plasma with a plasmin-rich reagent. The alpha-2 antiplasmin in the sample inhibits the plasmin. Residual plasmin activity is then determined using a substrate reaction that produces a measurable signal (e.g., light absorption), inversely proportional to the alpha-2 antiplasmin concentration.Clinicians may order this test to aid in diagnosing congenital alpha-2 antiplasmin deficiency, differentiating disseminated intravascular coagulation (DIC) from hyperfibrinolysis, and monitoring therapy with fibrinolytic or antifibrinolytic medications.
Example 1: A patient presents with symptoms suggestive of disseminated intravascular coagulation (DIC).The physician orders an alpha-2 antiplasmin assay (85410) to help differentiate DIC from other conditions causing excessive bleeding., A patient is diagnosed with congenital alpha-2 antiplasmin deficiency.Regular monitoring of alpha-2 antiplasmin levels (85410) is necessary to manage the condition and assess the effectiveness of treatment., A patient is receiving treatment with a thrombolytic agent (e.g., tPA) to dissolve a blood clot.Serial alpha-2 antiplasmin assays (85410) are performed to monitor the patient's response to the therapy and detect any potential complications.
* Patient demographics and identifiers.* Physician's order specifying the alpha-2 antiplasmin assay.* Date and time of specimen collection.* Method used for the assay.* Results of the alpha-2 antiplasmin assay, including units of measurement.* Clinician's interpretation of the results.* Relevant clinical information, including patient's medical history, symptoms, and medications.
** Always verify the appropriate code based on the specific methodology used and any additional services rendered.Payers may have specific requirements and coverage policies for this test.Consult with a coding specialist to address any unusual or complex coding scenarios.
- Revenue Code: T1H (LAB TESTS - OTHER)
- RVU: This information is not provided in the source.RVUs are dependent on various factors, including geographic location and payer.
- Global Days: Not applicable; this is a laboratory test.
- Payment Status: Active
- Modifier TC rule: Not applicable; this is a laboratory analysis.
- Fee Schedule: Fee schedule data is not available in the source. Historical fee information varies significantly by payer and location.
- Specialties:Hematology, Oncology, Thrombosis, Critical Care
- Place of Service:Office, Hospital (Inpatient and Outpatient), Clinical Laboratory