2025 CPT code 86258

Testing for antibodies against deamidated gliadin peptides (DGP), for each immunoglobulin (Ig) class (e.g., IgG, IgA).

One unit of 86258 is reported for each immunoglobulin class tested (e.g., IgG, IgA). This code is preferred over less specific codes for DGP testing.

Modifiers may be applicable, including 90 (reference outside lab), 91 (repeat test), and others as appropriate.

Medical necessity for this test is established when a patient presents with symptoms or signs suggestive of celiac disease, or for monitoring adherence to a gluten-free diet in diagnosed patients.

The laboratory analyst performs the test, typically using ELISA, to detect DGP antibodies in a serum specimen. While not exclusive to celiac disease, clinicians order this test to aid in diagnosis and monitor treatment adherence.

In simple words: This test looks for specific proteins (antibodies) in your blood that are associated with celiac disease.Celiac disease is a condition where your body reacts badly to gluten, a protein found in wheat, rye, and barley. The test helps doctors diagnose celiac disease and check if the treatment is working.

This code represents a test to identify antibodies to deamidated gliadin peptides (DGP), such as DGP IgG or DGP IgA, in a specimen like serum.The test is commonly performed using an immunoassay like ELISA (enzyme-linked immunosorbent assay). The presence of these antibodies aids in diagnosing celiac disease. The test can help monitor patient adherence to a gluten-free diet.

Example 1: A patient presents with digestive issues, and the physician orders a DGP antibody test (86258) to evaluate for celiac disease., A patient diagnosed with celiac disease has a DGP antibody test (86258) performed to assess their response to a gluten-free diet., A patient with a family history of celiac disease undergoes DGP antibody testing (86258) as part of a screening process.

Documentation should include the patient's symptoms, reason for testing, specimen type, and the test method used.

** A positive result may necessitate further testing, such as a titer, to quantify the antibody levels.Some payers may reimburse separately for specimen collection.

  • Revenue Code: T1H (LAB TESTS - OTHER (NON-MEDICARE FEE SCHEDULE))
  • Payment Status: Active
  • Specialties:Gastroenterology, Pathology, Internal Medicine
  • Place of Service:Independent Laboratory, Office, Outpatient Hospital
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