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BETA v.3.0

2025 CPT code 86603

Antibody; adenovirus

Report one unit per immunoglobulin class (IgG, IgM) or per adenovirus species/type. Check payer guidelines on using modifiers (91, 59) for distinct tests. Do not use this code for antigen detection.

Modifiers 91 (repeat test) and 59 (distinct procedural service) may be applicable. Modifier 90 indicates the test was performed by an outside laboratory.

Medical necessity is established by the clinical indication for the test, such as symptoms suggestive of an adenovirus infection.

The lab analyst performs the technical aspects of the test, including reacting the specimen, incubation, adding detection agents, and interpreting results.

IMPORTANT:For single-step methods like reagent strip tests, use 86318. For quantitative tests, use 86317. For procedures not found between 86015-86835 and not part of Chemistry (82009-84830), use 86849.

In simple words: This test checks your blood or spinal fluid for signs of a past or current adenovirus infection. Adenovirus can cause respiratory problems, pink eye, and other illnesses.

Immunoassay for adenovirus antibodies. This multi-step, qualitative or semi-quantitative test analyzes patient serum or cerebrospinal fluid (CSF) for adenovirus antibodies. The test aids in diagnosing respiratory conditions, conjunctivitis, or other adenovirus-related infections.Methodologies include enzyme immunoassay (EIA) or enzyme-linked immunosorbent assay (ELISA). The process may involve reacting the specimen with test antigens, incubation, adding a detection agent (stain, fluorescence, or other marker), and interpreting results.

Example 1: A patient presents with symptoms of a respiratory infection, and the physician orders an adenovirus antibody test (86603) to determine if adenovirus is the cause., A child with conjunctivitis has a 86603 test performed to confirm adenoviral conjunctivitis., A patient with a compromised immune system undergoes testing for various viral infections, including adenovirus (86603), to guide treatment.

Documentation should include the reason for the test, the specimen source (serum or CSF), the test methodology used, and the test results (positive, negative, or semi-quantitative value).

** Specimen collection codes (e.g., 36415 for venipuncture, 62270 for lumbar puncture) may be billed separately.

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