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BETA v.3.0

2025 CPT code 87301

Infectious agent antigen detection by immunoassay technique (e.g., EIA, ELISA, FIA, IMCA), qualitative or semiquantitative; adenovirus enteric types 40/41.

For multiple specimens/sites, use modifier 59. For repeat laboratory tests performed on the same day, use modifier 91. Do not report this code for testing culture isolates; other codes (e.g., 87140-87158) should be used instead.

Modifiers 59 and 91 are applicable.

Medical necessity is established by the patient's presenting symptoms and the clinical need to determine if adenovirus enteric types 40/41 are the cause of the gastrointestinal illness.

The laboratory analyst performs all technical steps of the immunoassay, using a primary source specimen (e.g., stool). They are responsible for ensuring the accurate identification of adenovirus enteric types 40 and 41 antigens.

In simple words: This test checks for specific particles (antigens) from the adenovirus that causes stomach problems, particularly in children. It uses a sample of your stool to see if the virus is present.

This code represents the laboratory test for detecting antigens of adenovirus enteric types 40 and 41 using immunoassay techniques such as enzyme immunoassay (EIA), enzyme-linked immunosorbent assay (ELISA), fluorescence immunoassay (FIA), or immunochemiluminometric assay (IMCA).The test is either qualitative or semiquantitative and utilizes a primary source specimen from the patient, typically stool.

Example 1: A 2-year-old child presents with diarrhea, vomiting, and fever. The physician orders this test to determine if adenovirus enteric types 40/41 is the cause., An immunocompromised patient experiences persistent diarrhea. This test is used to rule out adenovirus enteric infection as a contributing factor., A public health investigation of a gastroenteritis outbreak includes using this test on stool samples to identify the prevalence of adenovirus enteric types 40/41 among affected individuals.

Documentation should include the patient's symptoms, reason for testing, the specimen source, the test method used, and the results. Any relevant clinical findings supporting the medical necessity of the test should also be documented.

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