2025 CPT code 87480

Detects Candida species using a direct nucleic acid probe technique.

Follow CPT guidelines for microbiology procedures. Use modifier 59 for multiple specimens/sites, and modifier 91 for repeat tests on the same day.The molecular diagnostic codes (e.g., 81161, 81200-81408) are not to be used in combination with or instead of codes 87140-87158.

Modifiers 59 and 91 are applicable.

Medical necessity for 87480 is established when there is a clinical suspicion of Candida infection based on patient symptoms, risk factors (e.g., immunocompromised status, antibiotic use), or other clinical findings. The test results help guide treatment decisions.

The lab analyst performs all technical steps, including specimen preparation, probe hybridization, and visualization of the results. Clinicians order this test to aid in the diagnosis of Candida infections.

IMPORTANT For Candida antibody tests or skin tests, use 86628 or 86485.Distinguish between 87480 (direct probe), 87481 (amplified probe), and 87482 (quantification) for Candida testing.

In simple words: This lab test checks for Candida (a type of yeast) in a sample from your body, like a swab.It uses a special technique to detect the yeast's genetic material.

This CPT code, 87480, represents the laboratory procedure for detecting Candida species using a direct nucleic acid probe technique.The procedure involves the use of a single-stranded DNA or RNA probe that hybridizes with complementary sequences in the patient's specimen (e.g., vaginal swab, sputum). The probe is labeled (radioactive or chemical tag) for visualization of hybridization. This test helps diagnose Candida infections.

Example 1: A patient presents with symptoms of a vaginal yeast infection (vaginitis). A vaginal swab is collected, and the 87480 test is performed to detect Candida species., A patient with suspected oral thrush (Candida infection of the mouth) provides a saliva sample. The 87480 test is used to confirm the presence of Candida., A patient with a compromised immune system experiences symptoms consistent with a systemic Candida infection.Blood cultures and other specimens are tested using 87480 to assess the extent of infection.

* Patient demographics and unique identifier* Clinical indication for testing (e.g., symptoms, risk factors)* Specimen type and collection date/time* Test results with interpretation* Physician's order

** This code is for direct probe testing.Amplified probe (87481) and quantification (87482) tests are coded separately.

  • Revenue Code: T1H (LAB TESTS - OTHER (NON-MEDICARE FEE SCHEDULE))
  • Payment Status: Active
  • Modifier TC rule: Not applicable.
  • Specialties:Medical Microbiology, Infectious Disease, Pathology
  • Place of Service:Office, Hospital, Laboratory
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