2025 CPT code 88264
Effective Date: N/A Pathology and Laboratory Procedures - Cytogenetic Studies Pathology and Laboratory Feed
Chromosome analysis; analyze 20-25 cells.
Medical necessity for chromosome analysis is determined by the presence of specific clinical indications, such as suspected genetic disorders, developmental delays, congenital anomalies, infertility, or certain types of cancer.The ordering physician must document the clinical rationale for the test.
The clinical responsibility for this procedure lies with the laboratory personnel who perform the analysis, interpret the results, and report them to the ordering physician.
In simple words: A chromosome analysis is a laboratory test that examines your chromosomes for any changes or abnormalities.The test involves analyzing 20 to 25 cells to create a picture of your chromosomes, called a karyotype. This helps doctors diagnose certain genetic conditions or predict potential health problems.
This procedure involves a chromosome analysis where 20 to 25 cells are analyzed.The process includes counting the chromosomes in each cell and arranging them to create a karyotype, which is a visual representation of the chromosomes.This helps identify abnormalities in chromosome number or structure.
Example 1: A pregnant woman has an abnormal first-trimester Down syndrome screening result, prompting amniocentesis and subsequent chromosome analysis (88264) of fetal cells to assess for chromosomal abnormalities like Down syndrome (Trisomy 21)., A child with developmental delays, dysmorphic features, and intellectual disability undergoes chromosome analysis (88264) of peripheral blood lymphocytes to determine if a genetic condition, such as a chromosomal microdeletion or duplication, is present., An adult with unexplained infertility undergoes chromosome analysis (88264) to identify any potential chromosomal abnormalities, such as balanced translocations, that could be contributing to their infertility.
Documentation should include the reason for the chromosome analysis, the source of the cells (e.g., peripheral blood, amniotic fluid, bone marrow), and any relevant clinical findings. The laboratory report should include the karyotype image, the interpretation of the results, and any identified chromosomal abnormalities.
- Specialties:Clinical Genetics, Pathology, Oncology, Obstetrics and Gynecology, Pediatrics
- Place of Service:Independent Laboratory, Outpatient Hospital, Inpatient Hospital