2025 CPT code 88358
(Active) Effective Date: N/A Revision Date: N/A Pathology and Laboratory Procedures - Morphometric Analysis Surgical Pathology Procedures Feed
Morphometric analysis of a tumor to evaluate DNA ploidy and other features.
Modifiers may be applicable depending on the circumstances of service delivery. Refer to the CPT codebook and other relevant guidelines for appropriate modifier usage.
Medical necessity for 88358 is established when morphometric analysis is deemed clinically necessary to assess tumor aggressiveness, prognosis, or treatment planning. This often occurs in cases of cancer where information about tumor characteristics is crucial for making informed treatment decisions. Justification based on the patient's clinical condition and the need for specific information provided by the test should be documented.
The pathologist is responsible for performing the morphometric analysis, interpreting the results, and generating a report.
In simple words: The pathologist examines a tumor sample under a special microscope to analyze its DNA and other features to help determine how aggressive the tumor is and what the outlook might be.
This CPT code, 88358, reports morphometric analysis of a tumor specimen.The pathologist uses image analysis microscopy to evaluate the tumor's DNA ploidy (chromosome content), along with assessing size, shape, and other relevant morphometric features such as nuclear characteristics, mitotic rate (cell division), and tumor-to-normal tissue volume ratio.This analysis helps assess tumor aggressiveness and prognosis, particularly for cancers like breast cancer.Note that other methods, like flow cytometry (coded as 88182), may also be used for DNA ploidy analysis.
Example 1: A breast biopsy is sent for morphometric analysis to assess tumor DNA ploidy and inform treatment decisions., A prostate resection specimen undergoes morphometric analysis to evaluate tumor aggressiveness and guide further management., A lung cancer sample is analyzed using 88358 to determine the prognosis and guide treatment planning.
* Patient demographics and relevant clinical information.* Detailed description of the tumor specimen (type, size, location).* Results of morphometric analysis, including DNA ploidy findings.* Pathologist's interpretation and diagnosis.* Images or digital data from the morphometric analysis.
** This code specifically addresses morphometric analysis for DNA ploidy assessment using image analysis microscopy.Other methods exist for DNA ploidy determination, and appropriate code selection depends on the specific technique employed.
- Revenue Code: T1G (LAB TESTS - OTHER)
- Payment Status: Active
- Modifier TC rule: The technical component (TC) modifier is not typically applicable to this code.
- Specialties:Pathology
- Place of Service:Hospital, Laboratory