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2025 CPT code 90759

Hepatitis B vaccine (HepB), 3-antigen (S, Pre-S1, Pre-S2), 10 mcg dosage, 3 dose schedule, for intramuscular use.

Refer to CPT guidelines for proper coding of immunizations and vaccines.This code represents the vaccine product only, and the administration code must be reported separately. Do not report this code with SARS-CoV-2 vaccine administration codes unless both vaccines are administered.

No modifiers are applicable to code 90759.

Medical necessity for the Hepatitis B vaccine is determined by risk factors such as age, occupation (healthcare worker, public safety personnel), lifestyle (IV drug use, multiple sexual partners), chronic liver disease, diabetes, end-stage renal disease, travel to endemic areas, or close contact with an infected individual.

The physician is responsible for ordering and ensuring the proper administration of the Hepatitis B vaccine, including verifying patient eligibility, selecting the appropriate formulation, and providing patient education regarding potential side effects and the vaccination schedule.

In simple words: This code represents the Hepatitis B vaccine that protects against the hepatitis B virus. It is given in a series of three shots to adults. It does not include the cost of giving the shot.

This code represents the product cost of the Hepatitis B vaccine, specifically the 3-antigen (S, pre-S1, pre-S2) formulation with a 10 mcg dosage, administered intramuscularly as a 3-dose series.It is used for adults 18 years and older. This code does not include the administration of the vaccine, which is reported separately.

Example 1: A 25-year-old healthy adult presents to the clinic for a routine check-up and requests the Hepatitis B vaccine. The provider orders 90759 for the vaccine product and 90471 for the intramuscular administration., A 40-year-old patient with diabetes is seen at the clinic and is determined to be at increased risk for Hepatitis B.The provider orders 90759 for the vaccine product and 90471 for the intramuscular administration., An 18-year-old college student is starting a healthcare program and requires the Hepatitis B vaccine.The provider orders 90759 for the vaccine product and 90471 for the intramuscular administration.

Documentation should include the patient's age, the vaccine manufacturer (PreHevbrio), the dosage administered (10 mcg), the route of administration (IM), the site of administration, the lot number and expiration date of the vaccine, and any adverse reactions.

** PreHevbrio is approved for use only in adults 18 years and older and is administered as a two-dose series at 0 and 1 month. It is also available as a three-dose series, administered at 0, 1, and 6 months.  Always refer to updated guidelines and manufacturer instructions.

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