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2025 CPT code 96372

Therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscular.

The injection must be administered under the direct supervision of a physician or other qualified healthcare professional.Only one initial service code should be reported per day unless protocol requires two separate IV sites. Appropriate modifiers may be needed to address multiple injections or other circumstances.

Modifiers may be applicable in certain circumstances. Modifier 59 may be used if the injection is a distinct procedural service from other procedures performed on the same day.Consult the CPT manual and payer guidelines for additional modifier rules.

Medical necessity for this code will be determined based on the patient's diagnosis, the appropriateness of the medication, and the absence of other effective treatment options.Documentation should clearly support the clinical indication for the injection.

The physician or other qualified healthcare professional is responsible for overseeing the entire process, including assessment, treatment planning, and direct supervision of staff administering the injection.The administration itself may be performed by a nurse or assistant under direct supervision.

IMPORTANT:For administration of vaccines/toxoids, use codes 90460, 90461, 90471, 90472, 90473, 90474, 90480. For non-antineoplastic hormonal therapy injections, use code 96372. For anti-neoplastic nonhormonal injection therapy, use code 96401. For anti-neoplastic hormonal injection therapy, use code 96402. For intradermal cancer immunotherapy injection, use codes 0708T, 0709T.For allergen immunotherapy injections, use codes 95115-95117.Related codes include 96373-96376 for different injection methods and subsequent administrations.

In simple words: This code covers giving a shot (injection) of medicine under the skin or into a muscle.The medicine could be for treatment, prevention, or diagnosis. It does not include vaccines, cancer treatments, or certain hormone injections.

This CPT code encompasses the administration of a therapeutic, prophylactic, or diagnostic injection of a specified substance or drug via the subcutaneous or intramuscular route.It excludes the administration of vaccines/toxoids, antineoplastic hormonal therapy, and anti-neoplastic nonhormonal injection therapy.The injection must be performed under the direct supervision of a physician or other qualified healthcare professional.Additional codes may be necessary for the administration of multiple substances or drugs or for subsequent injections.

Example 1: A patient receives an intramuscular injection of a corticosteroid for a flare-up of rheumatoid arthritis., A patient receives a subcutaneous injection of a biologic medication for treatment of psoriasis., A patient receives a subcutaneous injection of vitamin B12 for treatment of a deficiency.

Detailed documentation should include the date and time of the injection, the substance or drug administered (including dosage and route of administration), the site of injection, and any patient reactions or adverse events.The physician's order and the treatment plan should also be documented.

** When billing for multiple injections of the same substance on the same date, use the appropriate add-on codes to reflect the additional injections. If the injection is part of a larger procedure, do not bill this code separately.The specific substance or drug must be documented on the claim form.

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