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BETA v.3.0

2025 CPT code 96405

Chemotherapy administration, intralesional; up to and including 7 lesions.

Use 96406 if more than seven lesions are treated.

Modifiers may be applicable to indicate specific circumstances of the procedure.

In simple words: The doctor injects chemotherapy medicine directly into a tumor or skin lesion to treat it. This code is used when the doctor treats up to seven lesions.

This code refers to the administration of chemotherapy drugs directly into a lesion or tumor. It is used when the provider treats one to seven lesions.

Example 1: A patient with Kaposi's sarcoma has five skin lesions. The physician injects chemotherapy directly into each lesion. Code 96405 is reported., A patient with melanoma has a single, palpable lesion. The physician injects chemotherapy directly into the tumor. Code 96405 is reported., A patient with basal cell carcinoma has two separate lesions. The physician injects chemotherapy directly into each lesion to treat the cancer. Code 96405 is reported.

Documentation should support the number of lesions treated, the drug and dosage administered, and the site of injection.

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