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2025 CPT code 99601

Home infusion/specialty drug administration, per visit (up to 2 hours).

Refer to the AMA CPT® coding guidelines for proper use of this code.Pay close attention to the guidelines on the use of modifier 25 when additional EM services are provided.

Modifiers may apply depending on the circumstances of the visit.Consult your payer's guidelines for appropriate modifier use. Modifier 25 may be used if a significant, separately identifiable EM service is performed in addition to the infusion/administration.

Medical necessity will be established by the physician's order for the home infusion or specialty drug administration.This should be documented in the patient's medical record and should reflect the patient's clinical condition, and the need for home infusion rather than administration in another setting.The documentation must support that the patient requires home-based care due to their condition.

The clinical responsibility includes the provider's arrival at the patient's home, preparation of infusion equipment/supplies, and administration of the infusion or specialty drug.This may involve intravenous lines, pumps, and careful monitoring of the patient's response to the medication.

IMPORTANT:Code 99602 is used for each additional hour beyond the initial two hours covered by 99601.Other related codes include 99341-99350 (E/M Home Visit codes, which may be used in conjunction with 99601-99602 if both services are performed).Modifier 25 may be added to 99601-99602 if a significant, separately identifiable E/M service is performed in addition to the home health service.

In simple words: This code covers a nurse's visit to a patient's home to give an infusion or special medicine. The visit can last up to two hours.

This CPT code reports home infusion or specialty drug administration for a visit lasting up to two hours.It encompasses the provider's arrival at the patient's home, preparation of infusion equipment and supplies (e.g., intravenous line connected to a pump for administering drugs at a prescribed rate), and administration of the infusion or drug.Additional time beyond the initial two hours is reported using code 99602.

Example 1: A patient receiving chemotherapy at home requires a registered nurse to administer the infusion. The nurse spends 1 hour and 30 minutes preparing the infusion, administering the medication, and monitoring the patient. Code 99601 is used to bill for this service., A patient with a chronic illness requires regular infusions of a specialty medication. The registered nurse visits the patient's home every week for a two-hour infusion. Code 99601 is billed for each visit., A patient needs a 3-hour infusion. Code 99601 is billed for the first 2 hours and code 99602 is billed for the additional hour.

Detailed documentation should include the date and time of the visit, the type and amount of medication administered, the duration of the infusion, any complications encountered, and the patient's response to the medication.Physician orders for the infusion should be included.Appropriate documentation to support medical necessity is crucial.

** The payer's specific guidelines regarding reimbursement for this code should be consulted.Consider the use of modifier 52 (Reduced Services) if the service provided is less than what is usually performed.

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