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2025 ICD-10-CM code A41.02

Sepsis due to methicillin-resistant Staphylococcus aureus (MRSA).

Use additional codes to identify the underlying cause or source of infection (e.g., postoperative wound infection, catheter-related bloodstream infection) and any associated organ dysfunction.

Medical necessity for treatment of MRSA sepsis is established by the presence of systemic infection with MRSA causing SIRS, potentially leading to organ dysfunction and death if left untreated.

Clinicians are responsible for diagnosing MRSA sepsis based on patient symptoms (fever, low blood pressure, rapid heart rate, difficulty breathing, altered mental status), physical findings, and laboratory tests (blood cultures, drug sensitivity testing).Treatment involves administering appropriate antibiotics, supportive care (fluids, oxygen), and addressing the source of infection (e.g., drainage of abscesses).

In simple words: Sepsis due to MRSA is a serious, potentially life-threatening condition where the body has an overwhelming immune response to a bloodstream infection caused by MRSA, a type of bacteria resistant to many common antibiotics.

A systemic inflammatory response syndrome (SIRS) resulting from a documented infection with methicillin-resistant Staphylococcus aureus (MRSA).MRSA is a strain of Staphylococcus aureus that is resistant to the antibiotic methicillin and other related beta-lactam antibiotics.

Example 1: A patient with a post-surgical wound develops fever, chills, and hypotension. Blood cultures are positive for MRSA, confirming the diagnosis of sepsis., An individual with an indwelling catheter develops fever and confusion.Blood cultures grow MRSA, indicating sepsis originating from the catheter site., A patient with a history of intravenous drug use presents with fever, rapid breathing, and altered mental status.Blood cultures reveal MRSA, establishing a diagnosis of MRSA sepsis.

Documentation should include signs and symptoms of sepsis, positive blood cultures for MRSA, antibiotic susceptibility results, and other relevant clinical findings (e.g., source of infection, presence of organ dysfunction).

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