2025 ICD-10-CM code C49.8

Malignant neoplasm of overlapping sites of connective and soft tissue. Primary malignant neoplasm of two or more contiguous sites of connective and soft tissue.

Use this code when a primary malignant neoplasm overlaps two or more contiguous sites of connective and soft tissue. Do not use this code if there is a more specific code for the combination of sites involved.

Medical necessity is based on the diagnosis of a malignant neoplasm requiring treatment to prevent further spread and complications.

Diagnosis based on history, physical exam, lab tests (flow cytometry, FISH), biopsy (fine needle or open), and imaging (X-ray, CT, MRI, PET). Treatment can include chemotherapy, radiation therapy, surgery, and targeted therapy depending on the stage and type of cancer.

In simple words: Cancer that affects multiple connected areas of the body's connective or soft tissues, such as muscles, tendons, ligaments, and cartilage.

Malignant neoplasm that involves two or more adjacent sites of the connective and soft tissues. This includes neoplasms of blood vessels, bursa, cartilage, fascia, fat, ligaments (except uterine), lymphatic vessels, muscle, synovia, and tendon (sheath).

Example 1: A patient presents with a malignant tumor involving the muscle and fascia of the upper arm., A biopsy reveals a malignant neoplasm affecting both the tendon and ligament of the ankle., A patient with a history of cancer has a recurrence affecting the soft tissue and cartilage of the rib cage.

Documentation of the involved sites, confirmation of malignancy through biopsy, imaging reports, and treatment plan.

  • Specialties:Oncology, Surgery, Pathology
  • Place of Service:Inpatient Hospital, Outpatient Hospital, Physician's Office
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