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2025 ICD-10-CM code C75

Malignant neoplasm of other endocrine glands and related structures.

Use additional codes from Chapter 4 to identify any functional activity associated with the neoplasm. For overlapping lesions, use subcategory .8 unless a specific combination code exists. Code malignant neoplasms of ectopic tissue to the site mentioned (e.g., ectopic pancreatic malignancy is coded to the pancreas). If multiple non-contiguous tumors exist at the same site, code each site separately.

Medical necessity must be established by documenting the signs, symptoms, and diagnostic findings that support the diagnosis of a malignant neoplasm. Treatment, whether surgical, medical, or radiation therapy, must be consistent with established guidelines for the management of the specific type and stage of malignancy.

Symptoms depend on the gland or structure involved. Diagnosis is based on history, symptoms, signs, physical examination, and blood tests to check hormone levels. Biopsy, ultrasound, CT scans, MRI, and PET scans are used for confirmation and staging. Treatment depends on the affected gland and stage of malignancy and may include surgery, chemotherapy, radiation therapy, and/or radiofrequency ablation.

In simple words: Cancer of other endocrine glands (like the parathyroid, pituitary, or pineal gland) and related structures.This means abnormal cells are growing in these glands and may spread to other parts of the body.

Malignant neoplasm of other endocrine glands and related structures (organs and other structures in the body that secrete hormones or hormone–like substances) refers to abnormal growth of endocrine gland cells that can multiply and spread to other areas of the body. This category includes codes for when the provider documents malignant neoplasm of an endocrine gland (such as the parathyroid, pituitary, or pineal gland) or structures related to these glands not represented by another code, as well as a code for when the neoplasm involves multiple glandular structures and a code for when the structure is not specified.

Example 1: A patient presents with elevated calcium levels, fatigue, and a mass in the neck. After further testing including blood work and imaging, a diagnosis of malignant neoplasm of the parathyroid gland is confirmed., A patient experiences a range of hormonal imbalances and symptoms. Imaging reveals a malignant neoplasm of the pituitary gland., A patient undergoes a biopsy of a suspicious growth in the neck. Pathology confirms a malignant neoplasm of the carotid body.

Documentation should include details of the patient's symptoms, physical examination findings, results of blood tests showing hormone levels, imaging studies (ultrasound, CT, MRI, PET), biopsy results, and the physician’s diagnostic statement.Details of treatment, such as surgery, chemotherapy, or radiation should also be documented.

** Excludes1: malignant carcinoid tumors (C7A.0-), malignant neoplasm of adrenal gland (C74.-), malignant neoplasm of endocrine pancreas (C25.4), malignant neoplasm of islets of Langerhans (C25.4), malignant neoplasm of ovary (C56.-), malignant neoplasm of testis (C62.-), malignant neoplasm of thymus (C37), malignant neoplasm of thyroid gland (C73), malignant neuroendocrine tumors (C7A.-).

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