2025 ICD-10-CM code C84
(Valid) Effective Date: N/A Neoplasms - Mature T/NK-cell lymphomas 2: Neoplasms Feed
Mature T/NK-cell lymphomas.A group of rare and aggressive non-Hodgkin's lymphomas originating from mature T-cells or natural killer (NK) cells.
Medical necessity for treatment is based on the specific type and stage of the lymphoma, patient's overall health, and presence of symptoms. Treatment aims to control disease progression, alleviate symptoms, and improve survival.
Clinicians responsible for diagnosing and managing C84 (Mature T/NK-cell lymphomas) include hematologists/oncologists, pathologists, and radiation oncologists. They perform diagnostic tests (biopsy, immunophenotyping, imaging), determine the stage and subtype of the lymphoma, and develop a treatment plan, which may involve chemotherapy, radiation, stem cell transplantation, or targeted therapies. Regular follow-up care is essential for monitoring disease progression and managing long-term effects of treatment.
In simple words: Mature T/NK-cell lymphoma is a type of non-Hodgkin's lymphoma (NHL). It occurs when a type of white blood cell called T-cells or NK cells becomes cancerous.These lymphomas can be slow-growing or aggressive.
Mature T/NK-cell lymphomas are a heterogeneous group of lymphoproliferative disorders characterized by the abnormal proliferation of mature T-cells or natural killer (NK) cells. These lymphomas are typically rare and aggressive. Many subtypes exist, including mycosis fungoides, Sézary syndrome, peripheral T-cell lymphoma, and extranodal NK/T-cell lymphoma.
Example 1: A patient presents with painless swelling in the neck and armpit lymph nodes, along with night sweats and weight loss. Biopsy and immunophenotyping confirm peripheral T-cell lymphoma, a subtype of mature T/NK cell lymphoma (C84)., A patient experiences persistent nasal congestion and facial pain. A biopsy reveals extranodal NK/T-cell lymphoma, nasal type, classified under C84. Further tests confirm EBV association and staging is conducted to guide treatment., A child presents with skin rashes, enlarged lymph nodes, and fever. After extensive workup including biopsy and immunophenotyping, the diagnosis is confirmed as anaplastic large cell lymphoma (ALCL) a subtype of mature T/NK-cell lymphoma falling under C84.
Diagnosis requires histopathological confirmation from a biopsy of the affected tissue, such as a lymph node or skin lesion. Immunophenotyping, flow cytometry and genetic testing help further classify the specific subtype of mature T/NK cell lymphoma. Imaging studies (CT, PET) can assess the extent of disease and staging.
** Excludes1: personal history of non-Hodgkin lymphoma (Z85.72). Mature T/NK-cell lymphomas are rare and can involve various sites, including lymph nodes, skin, nasal cavity, and other extranodal locations. Prognosis and treatment depend on the specific subtype and stage of the lymphoma. Molecular genetic testing plays an important role in diagnosis and risk stratification.
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- Specialties:Hematology, Oncology, Pathology, Radiology
- Place of Service:Inpatient Hospital, Outpatient Hospital, Physician's Office