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2025 ICD-10-CM code C85.1

Unspecified B-cell lymphoma. This code is used when the provider does not document the specific type of B-cell lymphoma.

If a more specific type of B-cell lymphoma is identified, the corresponding code should be used instead of C85.1.

Medical necessity for diagnostic and treatment procedures is established by the confirmation of B-cell lymphoma through biopsy and the presence of related symptoms or evidence of disease progression.

Diagnosis of B-cell lymphoma involves a combination of patient history, physical examination focusing on lymph nodes, liver, and spleen, and diagnostic procedures. These include lymph node biopsy, blood tests (CBC, LDH, kidney and liver function tests, protein electrophoresis), and imaging studies (CT, MRI, PET) for staging. Treatment varies based on disease stage and severity, ranging from observation in asymptomatic cases to radiation for localized disease and chemotherapy for advanced stages.

In simple words: B-cell lymphoma is a type of non-Hodgkin lymphoma (NHL).It occurs when B lymphocytes become abnormal and multiply, accumulating in the lymph nodes. This type is not otherwise specified.

Unspecified B-cell lymphoma.If B-cell lineage or involvement is mentioned in conjunction with a specific lymphoma, code to the more specific description.

Example 1: A patient presents with painless, swollen lymph nodes in the neck and armpits, along with fatigue and night sweats. Biopsy confirms B-cell lymphoma, but the specific type isn't identified, so C85.1 is used., During a routine physical, a patient is found to have an enlarged spleen. Further imaging and biopsy reveal B-cell lymphoma, but the specific subtype isn't determined.C85.1 is the appropriate code., A patient with a history of recurring fevers and weight loss undergoes a PET scan, which reveals abnormal activity in multiple lymph node groups.Biopsy shows B-cell lymphoma, but the subtype is not specified. C85.1 is used for coding.

Documentation should include details of the biopsy confirming B-cell lymphoma, along with any associated symptoms (swollen lymph nodes, fatigue, night sweats, etc.), blood test results, and imaging findings. The absence of a specific subtype diagnosis should also be clearly documented.

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