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2025 ICD-10-CM code C90.12

Plasma cell leukemia in relapse.

Use this code only when there is documented evidence of relapse following a period of remission. If the disease has not achieved remission after initial treatment, use code C90.10, Plasma cell leukemia, not having achieved remission.

Medical necessity for treatment of relapsed plasma cell leukemia is based on the presence of signs and symptoms, disease progression, and the potential for complications. Treatment aims to control the disease, alleviate symptoms, and improve quality of life.

Diagnosis and management of plasma cell leukemia typically involves hematologists/oncologists.They perform bone marrow biopsies, blood tests, and imaging studies to diagnose and stage the disease. Treatment options include chemotherapy, stem cell transplantation, radiation therapy, and supportive care.

In simple words: This code is used when a person's plasma cell leukemia, a type of bone marrow cancer, has come back after treatment had initially caused it to disappear.

Plasma cell leukemia is a type of multiple myeloma characterized by the abnormal proliferation of plasma cells in the bone marrow.This code specifies that the leukemia has returned after a period of remission.

Example 1: A patient with a history of plasma cell leukemia, treated two years prior and in remission, presents with fatigue, bone pain, and recurrent infections.Blood work reveals anemia and elevated calcium levels.A bone marrow biopsy confirms relapsed plasma cell leukemia., A patient undergoing follow-up for plasma cell leukemia after completing chemotherapy shows evidence of increasing plasma cells in their blood work.Imaging studies confirm disease progression, indicating a relapse., A patient with plasma cell leukemia achieves complete remission after autologous stem cell transplantation, but one year later develops new bone lesions and increasing paraprotein levels, consistent with disease relapse.

Documentation should include details of the initial diagnosis and treatment, the period of remission, evidence of relapse (e.g., blood tests, bone marrow biopsy, imaging results), and the planned treatment for the relapse.

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