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2025 ICD-10-CM code C95.00

Acute leukemia of unspecified cell type not having achieved remission.

Use additional codes to specify any associated conditions or complications. If the cell type is later identified, update the code to the more specific diagnosis.

The medical necessity for treatment of acute leukemia is established by the confirmed diagnosis. The unspecified nature of the leukemia type does not negate the need for treatment, as acute leukemias are aggressive cancers requiring prompt and intensive interventions.

Diagnosis involves physical exam, blood tests (CBC, peripheral smear, blood chemistries, coagulation studies), bone marrow biopsy or aspiration, lumbar puncture for CSF analysis, microscopic and cytologic analysis of CSF, blood, and/or bone marrow, flow cytometry, PCR, fluorescence in situ hybridization (FISH), genetic analysis, and imaging (CT, MRI, PET, ultrasound). Treatment may include chemotherapy, targeted chemotherapy, stem cell transplant, radiation therapy, and surgery.

In simple words: This refers to a type of blood cancer called acute leukemia where the exact type of blood cell affected is unknown, and the disease hasn't gone into remission after treatment.

Acute leukemia of unspecified cell type not having achieved remission. This condition is characterized by the rapid proliferation of abnormal, immature white blood cells in the bone marrow and blood.The specific type of cell involved is not identified, and the disease has not responded to treatment to the point of remission.

Example 1: A 25-year-old patient presents with fatigue, bruising, and frequent infections.Blood tests reveal a high white blood cell count with blasts. Bone marrow biopsy confirms acute leukemia, but the specific cell type cannot be determined.After initial chemotherapy, the patient has not achieved remission., A 60-year-old patient with a history of recurrent infections is found to have abnormal blood counts. Bone marrow biopsy reveals acute leukemia of unspecified cell type. Despite treatment, the leukemia has not gone into remission and symptoms persist., A child presents with bone pain, fever, and pallor.Diagnostic tests reveal acute leukemia, but the specific cell lineage is unclear. Following multiple rounds of chemotherapy, the patient has not achieved remission, and the disease continues to progress.

Documentation should include evidence of diagnostic testing (blood tests, bone marrow biopsy, cytogenetic analysis, etc.) confirming the diagnosis of acute leukemia and specifying that the cell type is unspecified.It should also clearly indicate the lack of remission despite treatment. Patient's presenting symptoms, treatment history, and response to treatment should also be documented.

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