2025 ICD-10-CM code C96.2
Malignant mast cell neoplasm.
The medical necessity for procedures and treatments related to malignant mast cell neoplasm should be documented based on the individual patient's presentation, disease stage, symptoms, and treatment goals. Justification should consider current clinical guidelines and standards of care.
Diagnosis involves physical examination, patient history, and laboratory tests like CBC, peripheral smear, blood chemistries, and coagulation studies. Bone marrow biopsy or fine needle aspiration, cytologic analysis, flow cytometry, PCR, FISH, and imaging studies like CT, MRI, PET, and ultrasound can also be used. Treatment includes chemotherapy, targeted therapy (e.g., interferon), stem cell transplant, radiation therapy, and/or surgery, as determined by disease stage and patient age. Prognosis is generally poor, and treatment aims to manage symptoms and slow progression.
In simple words: Malignant mast cell neoplasm is a rare type of cancer where too many mast cells (a type of white blood cell involved in allergies) grow in the body. It can cause fatigue, weight loss, bone pain, skin rashes, and other problems.
Malignant mast cell neoplasm is a rare and aggressive form of mastocytosis characterized by the abnormal proliferation and accumulation of mast cells in the blood and body tissues.It's crucial to differentiate this from indolent mastocytosis (D47.02), mast cell leukemia (C94.30), and congenital/cutaneous mastocytosis (Q82.2).
Example 1: A 65-year-old patient presents with fatigue, bone pain, and enlarged spleen and liver. After a series of tests, including a bone marrow biopsy, a diagnosis of malignant mast cell neoplasm is confirmed., A 40-year-old individual with persistent skin rashes and unexplained weight loss is found to have abnormal mast cell accumulation in blood tests and a subsequent biopsy, leading to a diagnosis of malignant mast cell neoplasm., A child with recurrent unexplained allergic reactions and enlarged lymph nodes undergoes further evaluation, including genetic testing and imaging, which reveal a diagnosis of malignant mast cell neoplasm.
Documentation should include patient history, physical exam findings, complete blood count (CBC) results, peripheral smear findings, blood chemistry profiles, coagulation studies, biopsy results (bone marrow or fine needle aspiration), cytology analysis, flow cytometry results, PCR test results, FISH results (if performed), genetic analysis reports, immunohistochemistry reports, imaging results (CT, MRI, PET, and/or ultrasound), and treatment details including chemotherapy protocols, radiation therapy details, and any surgical procedures performed. Documentation should also capture details about response to treatment and disease progression.
- Specialties:Hematology-Oncology, Pathology, Internal Medicine, Dermatology
- Place of Service:Inpatient Hospital, Outpatient Hospital, Physician's Office, Independent Clinic, possibly others depending on the specific treatment provided.