In simple words: Chronic myeloproliferative disease is a type of slow-growing blood cancer where too many abnormal blood cells are made in the bone marrow.

Chronic myeloproliferative disease is a slow-growing blood cancer characterized by the uncontrolled multiplication of abnormal red blood cells, white blood cells, and platelets in the bone marrow, which then accumulate in the blood.

Example 1: A patient presents with fatigue, enlarged spleen, and elevated white blood cell count. After further testing, including bone marrow biopsy, a diagnosis of chronic myeloproliferative disease is confirmed., A patient experiences unusual bruising and bleeding. A CBC reveals abnormal platelet levels. Following genetic testing and bone marrow analysis, the patient is diagnosed with chronic neutrophilic leukemia, a subtype of chronic myeloproliferative disease., A patient has persistent fatigue and abdominal discomfort. After ruling out other potential causes, the physician orders a bone marrow biopsy, which leads to a diagnosis of unspecified myeloproliferative disease.

Documentation should include complete blood count results, bone marrow biopsy findings, genetic test results, and clinical symptoms such as fatigue, weight loss, abdominal discomfort, bruising, and enlarged spleen or liver.

** Excludes atypical chronic myeloid leukemia BCR/ABL-negative (C92.2-), chronic myeloid leukemia BCR/ABL-positive (C92.1-), myelofibrosis NOS (D75.81), myelophthisic anemia (D61.82), myelophthisis (D61.82), and secondary myelofibrosis NOS (D75.81).