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2025 ICD-10-CM code D64.3

Other sideroblastic anemias. This condition is characterized by the bone marrow producing ringed sideroblasts (abnormal red blood cells with iron rings around the nucleus) instead of healthy red blood cells.

Use this code when the documented diagnosis is other sideroblastic anemias or sideroblastic anemias not otherwise specified(NOS). Ensure proper documentation supports the specific type of sideroblastic anemia ruled out and the use of this more general code.

Medical necessity for the evaluation and treatment of other sideroblastic anemias is established by the presence of signs and symptoms such as fatigue, weakness, pallor, shortness of breath, and other related findings. Supporting laboratory results showing abnormal blood counts and iron levels, and the presence of ringed sideroblasts in the bone marrow are key indicators.

Diagnosis of other sideroblastic anemias is based on patient history, physical examination, and symptoms. Laboratory tests such as CBC, peripheral smear, and iron level assessments are crucial. Additional tests like bone marrow biopsy and genetic testing may be necessary. Imaging studies, including MRI, can also be used.

In simple words: Other sideroblastic anemia is a bone marrow disorder where your body makes abnormal red blood cells. These cells have rings of iron around their center, which prevents them from carrying oxygen effectively. This can cause symptoms like tiredness, weakness, and shortness of breath.

Other sideroblastic anemia refers to a disorder of the bone marrow in which there is production of abnormal red blood cells (RBCs), characterized by ring-like accumulation of iron in the nucleus. It may be inherited or acquired. The provider documents sideroblastic anemia not represented by other codes.A patient suffering from other sideroblastic anemias may experience fatigue, weakness, paleness, shortness of breath, sensation of racing heartbeat, chest pain, irritability, and at times, enlarged spleen and liver. Provider diagnoses the condition based on history, physical examination, and signs and symptoms. Laboratory tests include CBC, peripheral smear, and iron levels. Other tests such as bone marrow biopsy and genetic testing may be helpful. Imaging studies such as MRI can be conducted. Treatment includes vitamin B6 (pyridoxine) therapy, blood transfusions, and bone marrow transplantation.

Example 1: A 55-year-old male presents with persistent fatigue, shortness of breath, and pallor. After a thorough evaluation including blood tests and bone marrow biopsy, he is diagnosed with other sideroblastic anemia, specifically the subtype not further classified elsewhere., A 25-year-old female with a family history of blood disorders experiences increasing weakness and pale skin.Laboratory tests reveal iron overload and a bone marrow biopsy shows ringed sideroblasts.Genetic testing confirms a diagnosis of other sideroblastic anemia, distinguishing it from other genetic forms like X-linked sideroblastic anemia., A 60-year-old patient with a history of heavy alcohol use develops anemia.A bone marrow examination reveals ringed sideroblasts, leading to a diagnosis of other sideroblastic anemia related to alcohol use.This is differentiated from other acquired types like those caused by drug-induced or secondary to myelodysplastic syndromes.

Documentation should include complete blood count (CBC) results, peripheral blood smear findings, iron studies, bone marrow biopsy results (demonstrating ringed sideroblasts), and any relevant genetic testing or imaging studies. Patient history, including alcohol use, medication history, and family history of blood disorders, is also essential.It's important to specify that it's other sideroblastic anemia not classified in the other available codes and differentiate from specific diagnoses.

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