In simple words: LFA-1 deficiency is a genetic condition that weakens the immune system. It makes it hard for the body to fight off infections, even minor ones.Infections can become very serious quickly.

Lymphocyte function antigen-1 (LFA-1), also known as CD11a/CD18 defect, refers to a genetic defect which results in leukocyte adhesion deficiency type I (LAD I).This extremely rare immunodeficiency is characterized by a significant increase in the number of leukocytes (leukocytosis) but a lack of leukocyte recruitment at sites of infection. This lack of response continues until the infection becomes extensive and life-threatening.

Example 1: A newborn experiences delayed umbilical cord separation, persistent infections, and poor wound healing.Testing reveals LFA-1 deficiency., An infant presents with severe periodontitis, recurrent skin infections, and leukocytosis.Flow cytometry confirms a diagnosis of LFA-1 defect., A child experiences recurrent, severe bacterial infections requiring hospitalization. After extensive testing, they are diagnosed with LFA-1 deficiency.

Documentation should include family history, clinical findings (delayed umbilical cord separation, infections, periodontitis, etc.), laboratory results (CBC, flow cytometry), and imaging results (CT, MRI, bone scan).