2025 ICD-10-CM code D84.821
Immunodeficiency due to drugs. This condition is characterized by a weakened immune system resulting from medication use.
Medical necessity is established by the presence of clinically significant immunodeficiency resulting from medication use, requiring further evaluation and management.
Clinicians should document the specific medication causing the immunodeficiency, the severity of the immunodeficiency, and any related complications or infections. They should also consider any necessary adjustments to the patient's medication regimen.
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
- D80-D89 Certain disorders involving the immune mechanism
In simple words: This code indicates a weakened immune system caused by medications.
Immunodeficiency due to (current or past) medication. Use additional code for adverse effect, if applicable, to identify adverse effect of drug (T36-T50 with fifth or six character 5). Use additional code, if applicable, for associated long term (current) drug therapy, such as systemic steroids (Z79.52) or other long term (current) drug therapy (Z79.899).
Example 1: A patient receiving chemotherapy for cancer develops recurrent infections due to a weakened immune system., A patient on long-term immunosuppressants after an organ transplant experiences frequent opportunistic infections., A patient taking certain medications for an autoimmune disease develops an increased susceptibility to viral infections.
Documentation should include the type of medication, dosage, duration of use, clinical evidence of immunodeficiency (e.g., recurrent infections, lab results), and any other relevant medical history.
** This code was added in 2020. It is important to differentiate between immunodeficiency caused by drugs (D84.821) and adverse effects of drugs (T36-T50).
- Specialties:Immunology, Infectious Disease, Oncology, Hematology, Internal Medicine, Family Medicine, Primary Care
- Place of Service:Inpatient Hospital, On Campus-Outpatient Hospital, Off Campus-Outpatient Hospital, Office, Home, Skilled Nursing Facility