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2025 ICD-10-CM code E16.3

Increased secretion of glucagon. Hyperplasia of pancreatic endocrine cells with glucagon excess.

Use additional codes to specify any underlying conditions or associated manifestations, such as diabetes or skin lesions.

Medical necessity for services related to increased glucagon secretion is established by the presence of signs, symptoms, and diagnostic findings consistent with the condition.The documentation should support the need for the specific interventions and treatments provided.

Providers diagnose increased glucagon secretion based on medical history, physical exam, and symptoms.Diagnostic testing includes blood tests (fasting plasma glucose, hormone levels, amino acid levels) and imaging studies (CT, MRI, ultrasound) to identify pancreatic tumors. Treatment focuses on symptom relief, managing diabetes (with medication or insulin), treating skin rashes (amino acid and zinc supplements), and potentially surgery to remove tumors.

In simple words: Increased secretion of glucagon means your body is producing too much of a hormone that raises blood sugar. This can lead to skin rashes, diabetes, weight loss, blood clots, mental health issues, weakness, digestive problems, stomach pain, and ulcers.

Increased secretion of glucagon, a hormone that counteracts low blood sugar, refers to excess production of this hormone by specialized islet cells in the pancreas.Various factors can stimulate an increase in glucagon secretion, including hypoglycemia (low blood sugar), elevated levels of alanine or catecholamines, and other medical conditions.

Example 1: A patient presents with a persistent skin rash, weight loss, and elevated blood sugar levels. Diagnostic testing reveals increased glucagon secretion due to a pancreatic tumor., A patient with a history of hypoglycemia experiences recurrent episodes of high blood sugar. Further investigation reveals excessive glucagon secretion as a compensatory mechanism., A patient undergoing evaluation for unexplained weight loss and diabetes is found to have increased glucagon levels, prompting further assessment for underlying pancreatic abnormalities.

Documentation should include the following: complete medical history, physical exam findings, presenting symptoms, laboratory results (blood glucose, hormone levels, amino acid levels), imaging reports (if applicable), diagnosis, and treatment plan.

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