2025 ICD-10-CM code E16.4
(Active) Effective Date: N/A Endocrine, nutritional and metabolic diseases - Other disorders of pancreatic internal secretion 4 Feed
Increased secretion of gastrin.
Medical necessity for services related to E16.4 is established by the documented presence of signs, symptoms, and/or laboratory findings consistent with increased gastrin secretion. The documentation should support the need for diagnostic testing and/or treatment to address the underlying condition and manage associated complications.
Clinicians are responsible for diagnosing and managing increased secretion of gastrin. This involves evaluating patient symptoms, conducting appropriate laboratory and imaging studies, and determining the underlying cause. Treatment strategies aim to reduce gastrin levels and alleviate associated symptoms, which may include medication or surgical intervention.
In simple words: Overproduction of gastrin, a stomach hormone that helps digestion, can cause problems like diarrhea, nausea, and stomach pain.This can happen because of tumors, infections, or other medical issues. Doctors can diagnose this with blood tests and imaging scans, and treatment often includes medication or surgery.
Increased secretion of gastrin, a hormone that stimulates the production of gastric acid in the stomach. This condition, known as hypergastrinemia, can be caused by various factors, including gastrinomas (gastrin-secreting tumors), Helicobacter pylori infection, renal failure, vagotomy, and certain medications. It can lead to symptoms such as persistent diarrhea, nausea, vomiting blood, loss of appetite, and esophageal pain. Diagnosis typically involves blood tests for fasting gastrin levels, chromogranin A, and secretin stimulation tests, as well as imaging studies like CT, MRI, and ultrasound to locate potential tumors in the pancreas. Treatment often includes proton pump inhibitors and H2 antagonists to reduce acid secretion, and surgery may be necessary to remove gastrinomas.
Example 1: A patient presents with persistent diarrhea and abdominal pain. Blood tests reveal elevated gastrin levels, and an endoscopic ultrasound identifies a gastrinoma in the duodenum. The patient undergoes surgery to remove the tumor., A patient with chronic kidney disease experiences recurrent peptic ulcers. Testing reveals significantly elevated gastrin levels, attributed to impaired renal clearance of gastrin. The patient is treated with proton pump inhibitors to manage acid secretion., A patient develops symptoms of Zollinger-Ellison syndrome after undergoing a vagotomy. Diagnostic testing confirms increased gastrin secretion. Medical management with H2 blockers is initiated to control acid production.
Documentation for E16.4 should include details of the patient's symptoms (e.g., diarrhea, abdominal pain, nausea), laboratory results indicating elevated gastrin levels, imaging findings (e.g., presence of gastrinoma), and the treatment plan.
- Payment Status: Active
- Specialties:Gastroenterology, Endocrinology, General Surgery
- Place of Service:Inpatient Hospital, Outpatient Hospital, Office