In simple words: Gilbert syndrome is a harmless genetic condition where your liver doesn't process bilirubin efficiently.This can cause a slight yellowing of your skin and eyes sometimes, especially when you're sick or stressed.It doesn't usually cause problems and doesn't need treatment.

Gilbert syndrome (GS), also known as constitutional hepatic dysfunction and familial nonhemolytic jaundice, is a genetic disorder characterized by a deficiency in the enzyme uridine diphosphate-glucuronosyltransferase (UGT1A1). This enzyme is crucial for bilirubin conjugation in the liver.The reduced enzyme activity leads to elevated levels of unconjugated bilirubin in the blood (hyperbilirubinemia), which can manifest as intermittent jaundice, particularly during periods of stress, illness, or fasting.Gilbert syndrome is generally considered benign, often asymptomatic, and requires no specific treatment.

Example 1: A 20-year-old male presents with mild jaundice during a period of intense stress due to final exams. Blood tests reveal elevated unconjugated bilirubin, and other liver function tests are normal. The patient's history and exam findings are consistent with Gilbert syndrome., A routine blood test during a pre-employment physical reveals slightly elevated bilirubin levels in an otherwise healthy 30-year-old female. Further investigation and genetic testing confirm a diagnosis of Gilbert syndrome., A 17-year-old male experiences episodes of mild jaundice, abdominal discomfort, and fatigue, particularly when fasting or during illness.After ruling out other liver disorders, he is diagnosed with Gilbert syndrome based on his clinical presentation and laboratory results.

Documentation should include evidence of hyperbilirubinemia (predominantly unconjugated), normal liver function tests (excluding bilirubin), and a clinical picture consistent with Gilbert syndrome.Relevant patient history, such as episodes of jaundice triggered by stress, fasting, or illness, should also be documented.