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2025 ICD-10-CM code G47.421

Narcolepsy with cataplexy in the presence of another condition.

This code should never be used as a primary diagnosis. Always code the underlying condition first.

Medical necessity is established by the documentation of symptoms impacting daily life, such as excessive daytime sleepiness, cataplexy, sleep paralysis, and confirmation of the diagnosis through objective testing.

The physician is responsible for diagnosing narcolepsy with cataplexy through clinical evaluation, sleep studies (polysomnogram and multiple sleep latency test), and potentially hypocretin testing. They also manage the condition through lifestyle recommendations, medication (stimulants, SSRIs, tricyclic antidepressants, sodium oxybate), and treatment of underlying conditions.

IMPORTANT G47.411 (Narcolepsy with cataplexy, primary), G47.419 (Narcolepsy without cataplexy), G47.429 (Narcolepsy in conditions classified elsewhere without cataplexy)

In simple words: This code signifies narcolepsy with cataplexy (sudden muscle weakness) occurring alongside another health issue.Narcolepsy involves overwhelming daytime sleepiness and difficulty sleeping at night, often causing unexpected sleep episodes. Cataplexy can cause collapses. When this combination exists with another medical problem, this code is used, but the main health problem is coded first.

Narcolepsy in conditions classified elsewhere with cataplexy refers to a sleep disorder characterized by excessive daytime sleepiness, disturbed nighttime sleep, and sudden loss of muscle control (cataplexy) triggered by strong emotions. This code is used when narcolepsy with cataplexy occurs secondary to another diagnosed condition. The primary condition should be coded first.

Example 1: A patient with multiple sclerosis experiences excessive daytime sleepiness, cataplexy, and sleep paralysis. The MS is coded first, followed by G47.421., A patient with Parkinson's disease develops narcolepsy with cataplexy. Parkinson's disease is coded first, then G47.421., A patient with a traumatic brain injury experiences narcolepsy and cataplexy as a sequela. The brain injury is coded first, followed by G47.421.

Documentation should include a detailed medical history, sleep diary, physical exam findings, results of sleep studies (polysomnogram and multiple sleep latency test), hypocretin levels (if measured), and evidence of an underlying condition.

** It is crucial to distinguish between G47.411 (primary narcolepsy with cataplexy) and G47.421. The latter is specifically for cases where narcolepsy is secondary to another condition.

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