In simple words: Inclusion body myositis (IBM) is a rare muscle disease that causes weakness and wasting. It usually starts after age 50 and gets worse slowly over time. The weakness mainly affects the hands, fingers, forearms, lower legs, and feet. It makes everyday tasks like walking, climbing stairs, and gripping objects difficult. Some people also have trouble swallowing. IBM doesn't affect the heart, eyes, digestive system, bladder, brain, or senses, and rarely affects speech.

Inclusion body myositis (IBM) is a progressive muscle disorder characterized by muscle weakness, inflammation, and wasting.It primarily affects distal muscles (forearm, lower leg, and foot) more than proximal muscles, and muscle wasting follows. The onset of muscle weakness in IBM is generally gradual (over months or years). The weakness results in difficulty walking, lifting arms, and getting up from sitting and lying positions. Patients often experience difficulty with stairs, getting out of a chair, and have a poor grip. Varying degrees of difficulty swallowing (dysphagia) occur in about half of patients, but pain is uncommon. The disease typically does not affect muscles of the heart, eye, gut, or bladder. It does not affect the function of the brain or sensation, and speech is rarely affected.

Example 1: A 60-year-old male presents with progressive weakness in his hands and forearms, making it difficult for him to grip objects. He also reports frequent falls and difficulty climbing stairs. After a thorough examination and diagnostic testing, including a muscle biopsy, he is diagnosed with inclusion body myositis., A 55-year-old female experiences gradual weakness in her legs and feet, leading to frequent tripping and difficulty standing from a seated position. She also reports mild difficulty swallowing. Following clinical evaluation and diagnostic tests, including a muscle biopsy, a diagnosis of inclusion body myositis is confirmed., A 65-year-old male with a history of progressive muscle weakness in his hands and legs undergoes a muscle biopsy which reveals the presence of inclusion bodies, confirming the diagnosis of inclusion body myositis.

Documentation should include detailed medical history, physical and neurological exam findings, results of blood tests (electrolytes, CK levels), EMG, NCV, renal function tests, and muscle biopsy report confirming the presence of inclusion bodies.