2025 HCPCS code J0640
(In Use) Effective Date: N/A Revision Date: N/A Drugs - Drugs Administered Other than Oral Method Drugs, Administered by Injection Feed
Leucovorin calcium injection; supply of up to 50mg for IM or IV administration.
Modifiers may apply depending on the specific circumstances of administration and payer policies.Examples include modifier JW for drug wastage.
Leucovorin calcium is medically necessary in situations where there's a deficiency in folate, such as megaloblastic anemia, or when used as an antidote to counteract the effects of medications like methotrexate that interfere with folate metabolism.In cancer treatment, it's used to enhance chemotherapy effectiveness and mitigate toxicity.
Physician or other qualified healthcare professional responsible for ordering and overseeing the administration of the drug.
In simple words: This code covers the cost of the leucovorin calcium medication, used to treat anemia and counteract side effects of some other drugs, especially those used for cancer treatment. Up to 50mg can be billed with this code, given either as a shot into a muscle (IM) or into a vein (IV).This code does not include the cost of giving the injection itself.
This HCPCS code represents the supply of leucovorin calcium for intramuscular (IM) or intravenous (IV) injection, up to a maximum of 50 mg.Leucovorin calcium serves as an antidote for medications like high-dose methotrexate or certain antibiotics that interfere with folate production (also known as leucovorin rescue). It's also used to treat anemia from folic acid deficiency and, in conjunction with 5-fluorouracil, to improve survival in colorectal carcinoma patients.The code covers only the drug supply; administration is billed separately.If a portion of the vial is discarded after administration, modifier JW may be applicable.
Example 1: A patient receiving high-dose methotrexate for cancer treatment requires leucovorin calcium rescue to mitigate methotrexate's toxic effects on folate metabolism. J0640 is used to bill for the supply of leucovorin calcium., A patient presents with megaloblastic anemia due to folic acid deficiency.The physician orders leucovorin calcium injection to treat the anemia. J0640 is used to bill for the supply of the drug., A patient with colorectal cancer is undergoing chemotherapy with 5-fluorouracil. Leucovorin calcium is administered concurrently to enhance the efficacy of 5-fluorouracil and improve patient outcomes. J0640 bills for the leucovorin calcium supply.
Physician's order specifying the drug, dosage, and route of administration.Medical record documenting the diagnosis necessitating leucovorin calcium, including details on cancer treatment if applicable.Documentation of administration of the medication (a separate procedure code would be used for this).
** This code only represents the supply of leucovorin calcium.Separate codes are necessary for administration. Always verify payer-specific requirements for billing and coding accuracy.