2025 HCPCS code J2788

Rho(D) Immune Globulin, Mini-dose, IM

This code represents the drug only. The administration of the injection may be reported separately using CPT code 96372.

Modifiers may be applicable depending on the circumstances of the administration (e.g., JW modifier if a portion of the dose was discarded).

Medical necessity is established by the patient's Rh-negative blood type and the potential exposure to Rh-positive blood, either through pregnancy or certain procedures.

Administered by a healthcare professional to Rh-negative pregnant women, typically at around 28 weeks gestation and after delivery if the baby is Rh-positive to prevent sensitization.

IMPORTANT For a full dose (300 mcg/1500 IU), use J2790. Other related HCPCS codes for Rho(D) immune globulin include J2791 (100 IU, IM or IV) and J2792 (100 IU, IV, solvent detergent).The administration of this drug may be separately billable using CPT code 96372 (therapeutic, prophylactic, or diagnostic injection, SC or IM).

In simple words: This is a mini-dose of a medicine called RhoGAM, given as a shot into the muscle. It prevents Rh-negative mothers from developing antibodies against Rh-positive fetal blood.

Injection, Rho(D) immune globulin (human), mini-dose, 50 mcg (250 IU), for intramuscular administration.

Example 1: An Rh-negative woman at 28 weeks gestation receives a mini-dose of Rho(D) immune globulin intramuscularly., Following an amniocentesis or chorionic villus sampling, an Rh-negative woman receives J2788., An Rh-negative woman experiences a miscarriage or ectopic pregnancy and is administered J2788.

Documentation should include confirmation of the patient's Rh-negative blood type, the indication for administration (e.g., pregnancy, procedure), the dosage administered, and the route of administration (IM).

  • Payment Status: Active
  • Specialties:Obstetrics and Gynecology
  • Place of Service:Office, Outpatient Hospital, Inpatient Hospital
** Only Enterprise users with EHR integration can access case-specific answers. Click here to request access.