In simple words: Toxic liver disease is damage to the liver caused by harmful substances like drugs or toxins.

Toxic liver disease includes drug-induced idiosyncratic (unpredictable) liver disease and drug-induced toxic (predictable) liver disease. Use additional code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5). Excludes alcoholic liver disease (K70.-), Budd-Chiari syndrome (I82.0), hemochromatosis (E83.11-), Reye's syndrome (G93.7), viral hepatitis (B15-B19), and Wilson's disease (E83.01).

Example 1: A patient presents with jaundice, nausea, and elevated liver enzymes after starting a new medication. The clinician diagnoses drug-induced liver injury and codes it as K71., A patient is admitted to the hospital after intentionally ingesting a large quantity of acetaminophen. Laboratory tests reveal significantly elevated liver enzymes, consistent with toxic liver disease. The clinician codes it as K71, with an additional code for the acetaminophen poisoning (T39.1X5A)., A patient with a history of chronic alcohol abuse and recent exposure to industrial chemicals develops signs and symptoms of liver dysfunction. After a thorough evaluation, the physician determines that the liver damage is primarily due to chemical exposure, rather than alcohol. The clinician codes it as K71, along with an additional code for the specific chemical poisoning.

Documentation should include evidence of liver injury (e.g., abnormal liver function tests, imaging findings), the causative agent if known, and the clinical course of the condition. Additional documentation might be needed to support the use of any additional codes, such as poisoning or adverse drug reactions.