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BETA v.3.0

2025 ICD-10-CM code K75.2

Nonspecific reactive hepatitis.

It is crucial to exclude other types of hepatitis (viral, autoimmune, toxic) before using this code. Documentation should clearly state that other potential causes have been ruled out.

Medical necessity for K75.2 is established by the presence of signs, symptoms, and/or laboratory findings suggestive of liver inflammation, along with the documented exclusion of other specific liver conditions. The documentation must support the diagnosis and the need for further evaluation or treatment.

The clinician is responsible for diagnosing nonspecific reactive hepatitis by evaluating patient symptoms, medical history, conducting a physical examination, and ordering appropriate tests (such as blood tests, imaging studies, or liver biopsy) to rule out other causes and assess liver inflammation. They then manage the condition, which may involve treating the underlying cause, managing symptoms, or monitoring liver function to prevent further complications.

In simple words: This code signifies inflammation of the liver that isn't caused by a virus or toxic substance, and it's not a long-term (chronic) condition.It's a general term used when the cause of the liver inflammation is not clearly defined.

Nonspecific reactive hepatitis. Excludes1: acute or subacute hepatitis (K72.0-), chronic hepatitis NEC (K73.-), viral hepatitis (B15-B19). Excludes2: toxic liver disease (K71.-)

Example 1: A patient presents with fatigue, mild abdominal pain, and elevated liver enzymes. After ruling out viral hepatitis, autoimmune disorders, and toxic liver disease, the physician diagnoses nonspecific reactive hepatitis, likely drug-induced., A patient undergoing chemotherapy develops elevated liver enzymes.Viral and autoimmune hepatitis are ruled out, and the condition is diagnosed as nonspecific reactive hepatitis secondary to chemotherapy., A patient with a recent bacterial infection develops elevated liver enzymes and jaundice. After excluding other liver conditions, the doctor diagnoses nonspecific reactive hepatitis as a consequence of the infection.

Documentation should include signs, symptoms, laboratory results (elevated liver enzymes), imaging findings, and exclusion of other liver diseases.If a cause is suspected, it should also be documented.

** This is a diagnosis of exclusion, meaning other causes of liver inflammation must be ruled out before using this code.Using the code without proper documentation of exclusion of other conditions may lead to claim denial.

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